Annals of Surgical Oncology

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Routine Computer Tomography Imaging for the Detection of Recurrences in High-Risk Melanoma Patients

Tristen S. Park, Giao Q. Phan, James C. Yang, Udai Kammula, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 947-951

Background The use of routine CT imaging for surveillance in asymptomatic patients with cutaneous melanoma is controversial. We report our experience using a surveillance strategy that included CT imaging for a cohort of patients with high-risk melanoma. Methods A total of 466 patients with high-risk cutaneous melanoma enrolled in adjuvant immunotherapy trials were followed for tumor progression...

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Reliable Surgical Techniques for Lymphadenectomy Along the Left Recurrent Laryngeal Nerve During Thoracoscopic Esophagectomy in the Prone Position

Taro Oshikiri, Tetsu Nakamura, Hiroshi Hasegawa, Masashi Yamamoto, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 1018-1018

Background Lymphadenectomy along the left recurrent laryngeal nerve (RLN) in esophageal cancer is important for disease control¹ but requires advanced dissection skills. We previously reported a reliable method² for lymphadenectomy along the left RLN during thoracoscopic esophagectomy in the prone position (TEP). The goal of this method is complete dissection of the lymph nodes along the left...

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Ushering in a New Era for Regional Therapies

Kiran K. Turaga, T. Clark Gamblin, Robert Edwards, H. Richard Alexander, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 868-869

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Optimizing Follow-up Assessment of Patients with Cutaneous Melanoma

Neal Bhutiani, Michael E. Egger, Kelly M. McMasters

Annals of Surgical Oncology > 2017 > 24 > 4 > 861-863

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The Seven Best from PSOGI 2016

Paul H. Sugarbaker

Annals of Surgical Oncology > 2017 > 24 > 4 > 870-874

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Laparoscopic Glissonean Pedicle Transection (Takasaki) for Negative Fluorescent Counterstaining of Segment 6

Takashi Mizuno, Rahul Sheth, Masakazu Yamamoto, Hyun Seon C. Kang, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 1046-1047

Background The portal pedicles are wrapped in connective tissue known as the Walaeus sheath, which abut Laennec’s capsule covering the liver parenchyma. Precise knowledge of this anatomic relationship allows for dissection of this interspace and early control of the segmental portal pedicle (Glissonean pedicle transection method [GPTM], Takasaki approach).^1,2 Subsequent systemic administration of...

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Preclinical Evaluation of Cathepsin-Based Fluorescent Imaging System for Cytoreductive Surgery

Carlos H. F. Chan, Lukas F. Liesenfeld, Isabel Ferreiro-Neira, James C. Cusack

Annals of Surgical Oncology > 2017 > 24 > 4 > 931-938

Background Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal surface malignancies. The ability to detect microscopic foci of peritoneal metastasis intraoperatively may ensure the completeness of cytoreduction. In this study, we evaluated the suitability of a hand-held cathepsin-based fluorescent imaging system for intraoperative detection...

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Liver Resection After Selective Internal Radiation Therapy with Yttrium-90 is Safe and Feasible: A Bi-institutional Analysis

G. Paul Wright, J. Wallis Marsh, Manish K. Varma, Michael G. Doherty, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 906-913

Background Treatment with yttrium-90 (Y90) microspheres has emerged as a viable liver-directed therapy for patients with unresectable tumors and those outside transplantation criteria. A select number of patients demonstrate a favorable response and become candidates for surgical resection. Methods Patients who underwent selective internal radiation therapy (SIRT) with Y90 microspheres at two institutions...

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Prognostic Factors and Significance of Gastrointestinal Leak After Cytoreductive Surgery (CRS) with Heated Intraperitoneal Chemotherapy (HIPEC)

Konstantinos Chouliaras, Edward A. Levine, Nora Fino, Perry Shen, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 890-897

Background Gastrointestinal leak (GIL) after cytoreductive surgery with heated intraperitoneal chemotherapy (CRS/HIPEC) is associated with significant morbidity and mortality. This study aimed to identify GIL prognostic factors and its impact on overall survival. Methods A retrospective analysis of a prospectively maintained database comprising 1270 CRS/HIPEC procedures was performed. Type of GIL,...

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Inflammation-Based Prognostic Scores: Utility in Prognostication and Patient Selection for Cytoreduction and Perioperative Intraperitoneal Chemotherapy in Patients with Peritoneal Metastasis of Colonic Origin

Chukwuemeka Ihemelandu

Annals of Surgical Oncology > 2017 > 24 > 4 > 884-889

Background Tumor-associated systemic inflammatory response has been correlated with prognosis. Our aim was to analyze the utility of inflammation-based prognostic scores for prognostication and patient selection for cytoreduction and perioperative intraperitoneal chemotherapy (POIC) in patients diagnosed with peritoneal metastasis of colonic origin. Methods A retrospective analysis of a prospectively...

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Current Delivery of Hyperthermic Intraperitoneal Chemotherapy with Cytoreductive Surgery (CS/HIPEC) and Perioperative Practices: An International Survey of High-Volume Surgeons

Allison H. Maciver, Eisar Al-Sukhni, Jesus Esquivel, Joseph J. Skitzki, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 923-930

Background Cytoreductive surgery and heated intraperitoneal chemotherapy (CS/HIPEC) is performed for selected indications at a limited number of specialized centers worldwide. Currently there is no standardized approach to the perioperative care process. We sought to capture current practices in the perioperative management of patients who undergo CS/HIPEC at high-volume centers. Methods Surgeon...

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Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Adolescent and Young Adults with Peritoneal Metastases

Mashaal Dhir, Lekshmi Ramalingam, Yongli Shuai, Sam Pakrafter, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 875-883

Background Several studies suggest that young patients may derive less oncologic benefit from surgical resection of cancers compared with older patients. We hypothesized that young patients may have worse outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) for peritoneal metastases. Methods Perioperative and oncologic outcomes in adolescent and young...

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Management for Peritoneal Metastasis of Colonic Origin: Role of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy: A Single Institution’s Experience During Two Decades

Chukwuemeka Ihemelandu, Paul H. Sugarbaker

Annals of Surgical Oncology > 2017 > 24 > 4 > 898-905

Background Peritoneal metastasis of colonic origin is associated with a poor prognosis. This study aimed to analyze the clinicopathologic characteristics and prognostic predictors of survival in a cohort of patients treated with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (POIC) during two decades. Methods A retrospective study analyzed a prospectively maintained database...

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Comparison of Local Recurrence After Simple and Skin-Sparing Mastectomy Performed in Patients with Ductal Carcinoma In Situ

Simon Timbrell, Sarah Al-Himdani, Oliver Shaw, Kian Tan, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 1071-1076

Background The incidence of ductal carcinoma in situ (DCIS) is increasing with the use of screening mammography, and approximately 30% of all women diagnosed with DCIS are treated by mastectomy. There is increasing use of a skin-sparing mastectomy (SSM) approach to surgically excise DCIS as this facilitates immediate breast reconstruction. The rates of locoregional recurrence (LRR) after simple mastectomy...

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Harvest of at Least 23 Lymph Nodes is Indispensable for Stage N3 Gastric Cancer Patients

Gaozan Zheng, Fan Feng, Man Guo, Guanghui Xu, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 998-1002

Background The National Comprehensive Cancer Network (NCCN) recommends that at least 15 lymph nodes (LNs) be removed during radical gastrectomy. This study aims to investigate the optimal number of LNs resected for radical gastrectomy. Patients and Methods From September 2008 to March 2015, a total of 1990 gastric cancer patients were enrolled in this study. Clinicopathological features and survivals...

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Cytoreduction (Peritonectomy Procedures) Combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Advanced Ovarian Cancer: Retrospective Italian Multicenter Observational Study of 511 Cases

Angelo Di Giorgio, Pierandrea De Iaco, Michele De Simone, Alfredo Garofalo, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 914-922

Purpose The aim of this study was to help with the process of selecting patients with advanced ovarian cancer to undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) by analyzing outcome data at distinct clinical time points reflecting the natural history of the disease. Methods In a retrospective Italian multicenter study investigating patients with advanced...

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Identification and Characterization of CD107a as a Marker of Low Reactive Oxygen Species in Chemoresistant Cells in Colorectal Cancer

Tomohiro Kitahara, Naotsugu Haraguchi, Hidekazu Takahashi, Junichi Nishimura, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 1110-1119

Background Reactive oxygen species (ROS) generated by chemoradiotherapy lead to cancer cell death. Although ROS regulation mechanisms play important roles in chemoradioresistance, few markers exist that indicated intracellular ROS status. This study aimed to identify novel cell surface markers that represented intracellular ROS status to characterize cells with low ROS (ROS^low) in colorectal cancer...

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Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma

Shinya Okumura, Toshimi Kaido, Yuhei Hamaguchi, Atsushi Kobayashi, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 1037-1045

Background Decrease in skeletal muscle mass and function, known as sarcopenia, is associated with poor prognosis. Visceral fat accumulation also is related to mortality. This study investigated the impact of preoperative skeletal muscle mass, muscle quality, and visceral adiposity on outcomes in patients undergoing resection of intrahepatic cholangiocarcinoma (ICC). Methods A retrospective analysis...

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Impact of the Cross-Sectional Location of Multidetector Computed Tomography Scans on Prediction of Serosal Exposure in Patients with Advanced Gastric Cancer

Su Lim Lee, Young Mi Ku, Hae Myung Jeon, Han Hong Lee

Annals of Surgical Oncology > 2017 > 24 > 4 > 1003-1009

Background The extent of serosal exposure varies depending on the cross-section of the stomach that is viewed, affected by the visceral peritoneum of the omentum. Although multidetector computed tomography (MDCT) is the most useful method to predict serosal exposure, the MDCT criteria for such exposure by cross-sectional location remain to be established. Methods The MDCT of gastric cancer patients...

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Sentinel-Lymph-Node-Based Management or Routine Axillary Clearance? Five-Year Outcomes of the RACS Sentinel Node Biopsy Versus Axillary Clearance (SNAC) 1 Trial: Assessment and Incidence of True Lymphedema

Neil Wetzig, Peter Grantley Gill, David Espinoza, Rebecca Mister, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 1064-1070

Purpose To determine whether the benefits of sentinel-node-based management (SNBM) over routine axillary clearance (RAC) persisted to 5 years. Methods A total of 1088 women with breast cancer less than 3 cm in diameter and clinically negative axillary nodes were randomized to SNBM with axillary clearance if the sentinel node was positive or RAC preceded by sentinel-node biopsy. The outcomes were:...

INFONA - science communication portal

Annals of Surgical Oncology

Routine Computer Tomography Imaging for the Detection of Recurrences in High-Risk Melanoma Patients

Reliable Surgical Techniques for Lymphadenectomy Along the Left Recurrent Laryngeal Nerve During Thoracoscopic Esophagectomy in the Prone Position

Ushering in a New Era for Regional Therapies

Optimizing Follow-up Assessment of Patients with Cutaneous Melanoma

The Seven Best from PSOGI 2016

Laparoscopic Glissonean Pedicle Transection (Takasaki) for Negative Fluorescent Counterstaining of Segment 6

Preclinical Evaluation of Cathepsin-Based Fluorescent Imaging System for Cytoreductive Surgery

Liver Resection After Selective Internal Radiation Therapy with Yttrium-90 is Safe and Feasible: A Bi-institutional Analysis

Prognostic Factors and Significance of Gastrointestinal Leak After Cytoreductive Surgery (CRS) with Heated Intraperitoneal Chemotherapy (HIPEC)

Inflammation-Based Prognostic Scores: Utility in Prognostication and Patient Selection for Cytoreduction and Perioperative Intraperitoneal Chemotherapy in Patients with Peritoneal Metastasis of Colonic Origin

Current Delivery of Hyperthermic Intraperitoneal Chemotherapy with Cytoreductive Surgery (CS/HIPEC) and Perioperative Practices: An International Survey of High-Volume Surgeons

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Adolescent and Young Adults with Peritoneal Metastases

Management for Peritoneal Metastasis of Colonic Origin: Role of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy: A Single Institution’s Experience During Two Decades

Comparison of Local Recurrence After Simple and Skin-Sparing Mastectomy Performed in Patients with Ductal Carcinoma In Situ

Harvest of at Least 23 Lymph Nodes is Indispensable for Stage N3 Gastric Cancer Patients

Cytoreduction (Peritonectomy Procedures) Combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Advanced Ovarian Cancer: Retrospective Italian Multicenter Observational Study of 511 Cases

Identification and Characterization of CD107a as a Marker of Low Reactive Oxygen Species in Chemoresistant Cells in Colorectal Cancer

Impact of Skeletal Muscle Mass, Muscle Quality, and Visceral Adiposity on Outcomes Following Resection of Intrahepatic Cholangiocarcinoma

Impact of the Cross-Sectional Location of Multidetector Computed Tomography Scans on Prediction of Serosal Exposure in Patients with Advanced Gastric Cancer

Sentinel-Lymph-Node-Based Management or Routine Axillary Clearance? Five-Year Outcomes of the RACS Sentinel Node Biopsy Versus Axillary Clearance (SNAC) 1 Trial: Assessment and Incidence of True Lymphedema

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Annals of Surgical Oncology

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