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A 60-year-old woman complaining of abdominal discomfort was found at endoscopy to have a dome-shaped esophageal polyp, located 22cm from the incisor teeth and covered by normal epithelium. Histologic examination after endoscopic removal showed a submucosal esophageal gland adenoma. This is the ninth reported case of this entity. Eleven years later, the patient remains well with no evidence of esophageal...
Cancer of the esophagus and gastroesophageal junction (GEJ) in North America remains a relatively small but challenging clinical problem. It is estimated that, in 2004, 21 000 new esophageal cancers will be diagnosed (of which more than 75% will be in men) and 19 600 deaths from esophageal cancer will occur. In contrast to the Asian experience, adenocarcinomas of the esophagus and GEJ comprise more...
Background Neoadjuvant chemotherapy for advanced esophageal cancer is beneficial for responders, whereas it may provide no clinical benefits or even prove harmful in non-responders. Methods This study retrospectively compared the pathological findings and prognosis of 60 patients with UICC non-T4 stage III and IV, who received chemotherapy followed by surgery, and 96 patients with non-T4 stage III...
Endoscopic submucosal dissection (ESD) has gradually gained acceptance as one of the standard treatments for esophageal squamous cell carcinoma in Japan. Principal indications are little likelihood of nodal metastasis and having technical resectability. All lesions with preoperative diagnosis of high-grade intraepithelial neoplasms, including carcinomas in situ (T1a-EP), carcinomas invading the lamina...
Background Although lymph node metastasis is a significant prognostic factor in patients with esophageal cancer, the sensitivity and specificity of conventional imaging modalities such as computed tomography (CT) and magnetic resonance imaging is limited in the diagnosis of lymph node metastasis. This retrospective study examined the usefulness of the combination of 18F-fluorodeoxyglucose-positron...
Background Tachyarrhythmia after esophagectomy is a severe complication that should not be underestimated because of its negative impact. The aims of this study were to clarify the cause and impact of postoperative tachyarrhythmia after thoracoscopic esophagectomy. Additionally, we analyzed the usefulness of landiolol administration for postoperative tachyarrhythmia. Methods We evaluated the predictive...
Multimodality treatment strategies have become commonplace and stand-of-care in the management of esophageal cancer. In Japan, preoperative chemotherapy is routine, while in many centers around the globe chemoradiotherapy is widely practiced. How surgery should be integrated and the manner in which esophagectomy should be carried out remain controversial. From the literature, it seems that esophagectomy...
Background Although most esophageal non-epithelial tumors are benign tumors, such as leiomyomas, they also include gastrointestinal tumors (GISTs); thus, a histopathological diagnosis is indispensable to determine the optimal treatment strategy. However, no consensus has been reached as to the diagnostic methods and treatments for esophageal non-epithelial tumors. The purpose of this study was to...
Background This study was performed to clarify the optimal therapeutic strategy for recurrent disease after esophagectomy. Methods We investigated the prognosis of 37 patients who developed recurrence among 128 patients who underwent curative thoracoscopic esophagectomy (TE) at Kanazawa University Hospital. The prognostic factors after recurrence were examined by univariate and multivariate analyses...
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