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Cancer of the esophagus and gastroesophageal junction (GEJ) in North America remains a relatively small but challenging clinical problem. It is estimated that, in 2004, 21 000 new esophageal cancers will be diagnosed (of which more than 75% will be in men) and 19 600 deaths from esophageal cancer will occur. In contrast to the Asian experience, adenocarcinomas of the esophagus and GEJ comprise more...
This report concerns a 68-year-old man with an esophageal gastrointestinal stromal tumor (GIST) surgically resected after preoperative treatment. Endoscopic examination and the biopsy revealed the submucosal tumor in the lower esophagus to be c-kit gene positive, and we diagnosed the tumor as a GIST. Computed tomography showed a 124 × 74 × 115 mm mass with an unclear margin adjacent to the posterior...
Background Neoadjuvant therapy followed by surgery can improve long-term survival and reduce local recurrence in patients with esophageal squamous cell carcinoma (ESCC). Extracapsular lymph node involvement (ECLNI) reflects tumor progression in gastrointestinal malignancies. The aim of this study was to clarify the correlation between ECLNI and clinical outcome in ESCC following neoadjuvant therapy...
Background Preoperative chemotherapy using 5-fluorouracil and cisplatin is a standard treatment for stage II/III esophageal squamous cell carcinoma (ESCC) in Japan. However, stronger therapies are needed for advanced ESCC. This retrospective study aimed to evaluate the feasibility and safety of neoadjuvant chemoradiotherapy with R-DDP. Methods Patients diagnosed with clinical stage...
Background Although systemic therapy for esophageal carcinoma has advanced dramatically over the last several decades, the consensus of treatment for cervical esophageal carcinoma (CESCC) has yet remained controversial. Patients and methods We analyzed 56 CESCC patients who underwent various therapies in our hospital between January 2000 and December 2013. Results Thirteen cases underwent surgery...
Background Cervical esophageal cancer (CEC) is an uncommon disease. Thus, the clinical data from CEC patients have not been sufficient to establish a standard treatment. Methods Forty-six CEC patients who received definitive radiotherapy at our center from January 2003 to December 2014 were enrolled in this retrospective study. The stages of the patients according to the UICC 2002 staging system...
Background In patients treated surgically for esophageal cancer, time-dependent data on nutritional status from the perioperative to postoperative period are questionable. We investigated time-dependent data on weight, body composition, and nutritional indices of patients with esophageal cancer from the preoperative period through the 12-month postoperative period. Methods Eighty patients with esophageal...
Background The impact of sarcopenia on digestive cancer is widely known. Muscle mass, defined as the psoas muscle index (PMI), is an important parameter of sarcopenia. However, the relationship between esophageal cancer and PMI has not been fully investigated, especially in patients receiving neoadjuvant therapy. Methods To elucidate the influence of the PMI on patients with esophageal squamous...
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