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Although gastroesophageal reflux disease is sometimes associated with esophageal ulcer and/or mucosal erosion, acute upper gastrointestinal bleeding from an esophageal ulcer is uncommon. We report a case of acute gastrointestinal bleeding from one of multiple esophageal ulcers in extensive Barrett's esophagus in the postoperative period after low anterior resection performed for descending colon carcinoma...
Background It is difficult to predict the optimal therapeutic medicine for each gastroesophageal reflux disease (GERD) patient. This study aimed to clarify the frequency scale for symptoms of GERD (FSSG) questionnaire, which predicts the requirement of proton pump inhibitor (PPI) maintenance therapy. Methods The subjects were 255 GERD patients (107 male, mean age 51.4 ± 16.5 years) with reflux symptoms...
Background and aims In the Western world, 10–20 % of patients with GERD complain of at least weekly episodes of heartburn and/or acid regurgitation, while the corresponding value for GERD patients in Asia is <5 %. Reports of the risk factors for mucosal damage in patients with GERD are scarce. The aim of this study was to compare the severity of mucosal damage according to the Los Angeles system...
Background Gastroesophageal reflux disease (GERD) is a cause of dysphagia. Our aim in this investigation was to evaluate the duration of the oral and pharyngeal transit in patients with GERD, with the hypothesis that these patients may have an alteration of oral–pharyngeal transit. Method The swallow of 31 patients with GERD, 27 with erosive esophagitis, 15 with mild dysphagia for solid foods, and...
Objectives Multiple factors including genetic and environmental factors play a role in the pathogenesis of gastroesophageal reflux disease (GERD). The objective of this study was to quantitatively evaluate the association between Interleukin-1B-511 gene polymorphism and GERD susceptibility. Methodology Medline, CBM, VIP, CNKI, and Wanfang database were searched up to July 2014. Two reviewers independently...
Background Use of an endocytoscopy system (ECS) makes it possible to omit biopsy histology for esophageal squamous cell carcinoma (ESCC). However, for differential diagnosis of ESCC, the endocytoscopic characteristics of esophagitis should be clarified. Methods We examined the morphology of surface cells in 20 cases of gastroesophageal reflux disease (GERD) (Grade M: 6 cases, A: 5 cases, B: 1 cases,...
Background Gastroesophageal reflux disease (GERD) is one of the most frequent disorders in daily clinical practice with numerous associated consequences. A large number of studies were conducted to determine the prevalence of GERD and its associated risk factors which led to inconsistent results. The present study was performed to evaluate the prevalence of GERD and its related risk factors in north...
Background The aim of this study was to evaluate the differences in upper gastrointestinal symptoms between generations and genders in relatively healthy Japanese subjects. Methods Altogether, 4086 healthy Japanese male and female (M/F) adults (M/F: 2244/1842) were analyzed. Among them, 3505 subjects (M/F: 1922/1583) were underwent a routine medical checkup at one of five hospitals in Saga, Japan...
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