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Background Nedaplatin is an analogue of cisplatin with less nonhematologic toxicity. The combination of nedaplatin and 5-fluorouracil showed a promising response rate in a previous phase II study for metastatic esophageal cancer. The purpose of this study was to determine a recommended dose and to evaluate the efficacy of nedaplatin and 5-fluorouracil combined with concurrent radiotherapy. Methods...
Background Our objective was to review the results of surgical treatment for superficial esophageal cancer to obtain the proper indications for the recently proposed esophagus-preserving strategies. Methods The clinicopathological data of 290 consecutive patients with superficial thoracic or abdominal esophageal cancer who underwent esophagectomy with radical lymph node dissection without preoperative...
Background We analyzed the results of our surgical attempts to establish a safe reconstruction after esophagectomy for cancer that withstands both early and subsequent complications. Methods Patients who underwent an intrathoracic or cervical esophagogastrostomy were selected. We preserved the esophagus keeping an oral margin of at least 3 cm and made an anastomosis with the gastric wall as low...
A case of carcinosarcoma arising from the area of intraepithelial spread of relapsed esophageal squamous cell carcinoma (SCC) after definitive chemoradiotherapy (CRT) is reported herein. A 71-year-old man was referred to our hospital because of a superficial esophageal carcinoma. Definitive CRT was performed because the patient refused surgical treatment. Complete response was recognized after CRT,...
Background It is unknown whether the endoscopic appearance of local recurrent squamous cell esophageal cancer treated with definitive chemoradiotherapy is predictive of the subsequent clinical course. Methods We conducted a retrospective review of 19 patients with local recurrence. Local recurrence was classified into three types as seen by endoscopy. Of 19 local recurrences, 9 lesions were classified...
Lymph node metastasis of an esophageal cancer behind the thoracic descending aorta in the left pleural cavity is a rare form of tumor spreading that has not been reported in the English literature, to our knowledge. We report three patients who had this form of lymph node metastasis. Preoperative computed tomography (CT) scans of the chest could detect this disease. A left thoracotomy or approach...
Previous staging of esophageal cancer was based on a simple, orderly arrangement of increasing anatomic T, then N, then M classifications. This system is consistent with neither data nor cancer biology. Recent worldwide collaboration has provided data for unique, modern machinelearning analysis that has resulted in a new, data-driven staging system for cancer of the esophagus and esophagogastric junction...
Granular cell tumors of the esophagus are rare neoplasms and their diagnosis is mainly based on histopathologic examination of endoscopic biopsies. With the development of endoscopic techniques, there has been a marked increase in local treatment modalities for early esophageal neoplasms. In this case report, we describe the removal of a granular cell tumor by the endoscopic submucosal dissection...
Esophageal self-expandable metal stent placement is an effective treatment for palliation of malignant dysphagia, which has a low insertion-related complication rate. However, stent-related perforation can be a life-threatening event. We experienced a patient with advanced esophageal cancer who developed an iatrogenic esophageal perforation resulting from incorrect stent insertion. After removal of...
A 63-year-old man presented with a protruded tumor in the middle thoracic esophagus demonstrated by endoscopy. The tumor showed diffuse submucosal infiltrations, and the biopsy yielded a pathological diagnosis of adenocarcinoma. As an initial treatment, definitive chemoradiotherapy was performed. Although subsequent evaluations by endoscopy showed a good response, the lesion presented stenotic change...
Background Esophagectomy is the standard treatment for esophageal cancer, but has a high rate of postoperative complications. Some studies reported the various scoring system to estimate the postoperative complications. However, there were according to various surgical methods and included intra- and post-operative factors. Recently, minimally invasive esophagectomy (MIE) is becoming the first-line...
Background Endoscopic submucosal dissection (ESD) is the preferred treatment for esophageal squamous cell carcinoma (ESCC). However, ESD can be difficult when patients move due to insufficient sedation. We conducted a prospective confirmatory single arm study to evaluate the efficacy of using dexmedetomidine (DEX) in combination with midazolam as a novel sedation for ESD. Methods Endoscopic submucosal...
Background Dysphagia is a prominent symptom after esophagectomy and may cause aspiration pneumonia. Swallowing evaluation after esophagectomy can predict and help control the incidence of postoperative pneumonia. The aim of this study was to clarify whether the change in tongue pressure was associated with any related factor and postoperative dysphagia/pneumonia in patients with esophageal cancer...
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