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Background The characteristics of symptoms reported by patients with various organic and functional upper gastroduodenal diseases have not been fully studied. Methods We used a questionnaire-based survey to investigate abdominal symptoms of patients with reflux esophagitis, nonerosive reflux disease (NERD), peptic ulcers, and functional dyspepsia (FD). Seven hundred thirty-seven patients with those...
Background Standard chemoradiotherapy (CRT) using 5-FU and CDDP is the optimal treatment for patients with stage II/III (non-T4) esophageal carcinoma. However, patient quality of life (QOL) cannot necessarily be maintained during this therapy, because 5-FU must be continuously infused for 24 h and CDDP administration requires a large transfusion volume. Therefore, hospitalization is unavoidable. We...
Endoscopic submucosal dissection (ESD) recently has been aggressively performed to treat superficial esophageal cancer; however, it is difficult to secure a good field of view for mucosal dissection, and the technique requires considerable skill. We have developed a double-channel ESD method using an endoscopic esophageal mucosal resection (EEMR) tube that makes it possible to perform the submucosal...
We report a case of a 51-year-old man with esophageal cancer who had a complete pathological response to preoperative chemotherapy with a combination of docetaxel, cisplatin and 5-fluorouracil (DCF). Endoscopy and esophagography showed a type II tumor 8 cm in diameter, located in the upper thoracic esophagus. On computed tomography the diagnosis was T3N1M0, stage III disease according to TNM classification...
Background and objective Monitoring of central venous blood oxygen saturation (ScvO2) has recently become easier and safer to perform, but its clinical usefulness following esophagectomy has yet to be established. This study evaluated the use of continuous monitoring of ScvO2 in this setting, focusing on its relationship with hemoglobin (Hb) concentrations, and reconsideration about an appropriate...
Two randomized trials showed that survival was similar after definitive chemoradiation (CRT) or after CRT and surgery in locally advanced esophageal squamous cell cancer, despite more frequent local recurrences. In one trial randomization was done at inclusion, whereas in the other trial a workup was performed after initial CRT; only clinical responders were randomized between surgery and additional...
Purpose In Japan, chemoradiotherapy (CRT) is primarily indicated for T4 esophageal cancer for curative intent or when aiming for downstaging. However, CRT yields a low rate of complete response, is associated with a high incidence of complications such as fistula, and often results in the emergence of severe lymph node metastasis or distant organ metastasis after the therapy. A safer and more effective...
These data were first issued on 1 March, 2011, as the Comprehensive Registry of Esophageal Cancer in Japan, 2003. Not all pages are reprinted here; however, the original table and figure numbers have been kept. The authors were at the time members of the Registration Committee for Esophageal Cancer, the Japan Esophageal Society, and made great contributions in preparing this material.
The mainstay treatment for benign esophageal stricture is dilation with medical therapy. Although dilation usually provides symptomatic relief, recurrent refractory strictures often occur. Here we describe the treatment of a patient with a diffuse esophageal stricture caused by severe acid exposure from frequent vomiting during treatment of a duodenal ulcer. Administration of a proton pump inhibitor...
Purpose Chemoradiotherapy (CRT) has been performed for locally advanced thoracic esophageal carcinoma. To evaluate the outcome of induction CRT followed by esophagectomy, we compared it with that of definitive CRT. Patients Of 121 patients with T3–T4 squamous cell carcinoma who received CRT, 39 patients received induction CRT (total, 30–50 Gy) followed by esophagectomy and 82 patients received definitive...
A 64-year-old man visited our hospital complaining of abdominal discomfort. A 2-cm-long 0-IIc + IIa esophageal superficial carcinoma was detected in the middle third of the thoracic esophagus with endoscopy and esophagography. Computed tomography (CT) did not detect any metastasis. The patient underwent video-assisted thoracic surgery of the esophagus (VATS-E). Anastomotic leakage and a thoracic abscess...
Gastropericardial fistulae are rare and may cause fatal complications such as acute purulent carditis and cardiac tamponade. The present report describes a case of a gastropericardial fistula caused by a peptic ulcer perforating a retrosternal reconstructed gastric tube 2 years after subtotal esophagectomy for esophageal cancer. Surgical intervention involved left thoracotomy, pericardium fenestration,...
Esophageal achalasia is a primary motility disorder of the esophagus. Although various treatments can relieve the symptoms, esophageal cancer arising in patients with achalasia is the most important problem for long-term survivors. We encountered 2 cases of esophageal squamous cell carcinoma co-existing with achalasia that had been diagnosed 27 and 30 years earlier, respectively. Neither patient had...
Background Neoadjuvant chemotherapy (NACT) followed by surgery is a promising treatment strategy for advanced esophageal cancer. Response to NACT is a strong predictor for prognosis, but no studies have examined the relationship between toxicity and efficacy of NACT. Methods We retrospectively analyzed the treatment results of 105 patients with clinically node-positive esophageal cancer treated...
Background Many environmental and genetic factors are presumed to be involved in the etiology of esophageal squamous cell carcinoma (ESCC). We developed a health risk appraisal model that includes an alcohol flushing questionnaire (HRA-F) to estimate the ESCC risk. The purpose of this study was to use the HRA-F model to assess regional differences in the ESCC risk between rural and urban regions in...
Background We investigated the clinicopathologic features and long-term outcomes after surgery of Japanese women with esophageal cancer in comparison to those of men. Methods A total of 136 patients with esophageal cancer were surgically treated between 1996 and 2008 (22 [16.2%] women and 114 men). Gender differences in these patients were retrospectively investigated. Results Women undergoing...
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