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A new sol–gel hybrid methyltrimethoxysilane–mercaptopropyltrimethoxysilane (MTMOS–MPTMS) was synthesized, characterized and applied as sorbent for solid phase extraction (SPE) of selected non-steroidal anti-inflammatory drugs (NSAIDs) as target analytes. Analysis was performed using high performance liquid chromatography with UV detection at 234 nm. Under the optimum extraction conditions (100 mg...
This paper describes the development and comparison of the hydrolysis and esterification methods for the determination of 5-chlorothiophene-2-carbonylchloride (CTCC), a potential genotoxic impurity, in the drug rivaroxaban (RIVA) drug substance. Poor recovery of CTCC in the hydrolysis method occurred due to the high percentage of acetonitrile, which suppressed the hydrolysis reaction, but was solved...
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