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Carbamazepine (CBZ) and oxcarbazepine (OX) are highly effective anti-psychotic drugs. In USP, it is stated that CBZ has several impurities including, iminodibenzyl (IDB), iminostilbene (IMS), and 9-methylacridine (MA). While, for OX, it is reported to have impurities like, CBZ, IMS and 9-methylacridine (MA). Presence of such impurities in various forms may reduce the efficacy and increase the side...
Enzalutamide was recently approved for the treatment of castration-resistant prostate cancer. In this study, the related substances in enzalutamide bulk substance were analyzed qualitatively and quantitatively. Four degradation products (Oxi, A9, P1 and P2) of enzalutamide were isolated using semi-preparative liquid chromatography and characterized using nuclear magnetic resonance and mass spectrometry...
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