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The formation of the cartilage in mandible of human fetuses, which ranged from 12 to 32 weeks gestation, was systematically investigated with immunohistochemystry linked to an image color analyzer. One of the extracellular matrix proteins (type II collagen) was found mainly in the hypertrophic layer of the condyle from 16 weeks gestation. The percentage of type II collagen per 10,000μm2 area using...
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