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Amoebiasis, a worldwide explosive epidemic, caused by the gastrointestinal anaerobic protozoan parasite Entamoeba histolytica , infects the large intestine and, in advance stages, liver, kidney, brain and lung. Metronidazole (MNZ)—the first line medicament against amoebiasis—is potentially carcinogenic to humans and shows significant side-effects. Pyrazolo[3,4- d ]pyrimidine...
Telomere forms t-loop and G-quadruplex as the protective structure and the formation of these structures hinder the telomerase enzyme action. The binding affinities of ligand which stabilize the G-quadruplex represent good correlation with telomerase inhibition depicted in the anti-cancerous action. Most of the potent G-quadruplex stabilizing compounds suffer from the poor drug like properties. Herein,...
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