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Although induction of cell apoptosis is known to be involved in the cytotoxicity of Ni2+, little research has been aimed at the mechanism of Ni2+-induced apoptosis. Recent studies showed that Ni2+ induces histone hypoacetylation in different cell lines. Since histone hypoacetylation plays important roles in the control of cell cycle progress and apoptosis, we hypothesized that histone hypoacetylation...
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