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A core-shell nanocomposite consisting of polyaniline and gold nanoparticles (PANI@AuNPs) is shown to enable intracellular monitoring of pH values by surface-enhanced Raman scattering (SERS) spectroscopy. The method exploits the pH-responsive property of PANI and the SERS-enhancing effect of AuNPs. The intensity of the PANI Raman peak at 1164 cm−1 decreases on increasing the pH value from 4.6 to 7...
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