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Abstract Resistance to cyclodiene insecticides is associated with replacements of a single amino acid (alanine 302) in a -aminobutyric acid (GABA) receptor subunit encoded by the single-copy gene Resistance to dieldrin (Rdl). Alanine 302 is predicted to reside within the second membrane-spanning region of the Rdl receptor, a region that is thought to line the integral chloride ion channel pore. In...
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