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The SLC4 family consists of ten genes. All appear to encode integral membrane proteins with very similar hydropathy plotsconsistent with the presence of 1014 transmembrane segments. At least eight SLC4 members encode proteins that transport HCO3 (or a related species, such as CO32) across the plasma membrane. Functionally, these eight proteins fall into two major groups: three Cl-HCO3 exchangers (AE13)...
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