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Abstract. Using the whole-cell configuration of the patch-clamp technique, we quantified calcium release from the sarcoplasmic reticulum (SR) elicited by short depolarization pulses before and after clearance of the SR Ca2+ content with 10mM caffeine (CAF). With a loaded SR, the first detectable contraction occurred with a pulse duration of 5ms. CAF exposure increased this pulse duration to 85ms and...
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