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The first accounts of measuring cerebral blood flow (CBF) in humans were made by Angelo Mosso in ~1880, who recorded brain pulsations in patients with skull defects. In 1890, Charles Roy and Charles Sherrington determined in animals that brain pulsations—assessed via a similar method used by Mosso—were altered during a variety of stimuli including sensory nerve stimulation, asphyxia, and pharmacological...
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