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Abstract. Mutations in the gene encoding -synuclein (-syn) have recently been linked to rare hereditary forms of Parkinson's disease. A yeast two-hybrid screen with -synuclein (-syn) identified synphilin as an -syn-interacting protein, potentially implicating synphilin in the pathogenesis of synucleinopathies. Co-transfection of synphilin and the central (NAC) region of -syn in HEH293 cells resulted...
-, - and -synuclein are highly homologous proteins that are found predominantly in neurons. Abnormal accumulation of synucleins has been associated with diseases of the central nervous system particularly Parkinsons disease. Immunoreactivity of -synuclein is demonstrated in brain tumors with neuronal differentiation and in schwannomas, whereas -synuclein has been demonstrated in breast and ovarian...
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