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To investigate the prevalence and clinico-neuropathological characteristics of cerebral amyloid angiopathy (CAA) in aged Chinese and its relationship to dementia and cerebrovascular lesions, we examined 362 archived brains of elderly with immunohistochemical staining for -amyloid peptide and Congo red, Bodian and Luxol fast blue stains. We found that: (1) CAA appeared in 31.7% examined brains without...
A peptide deposits are observed in brain cortical and leptomeningeal microvessels in a few families, in patients with Alzheimers disease and in cognitively normal elderly subjects. These deposits, which cause A amyloid angiopathy, are usually associated with other lesions induced by A peptide and tau pathologies. To investigate the consequences of cerebral amyloid angiopathy on arterial morphology...
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