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The so-called “calcifying pseudoneoplasm of the neural axis” is a rare tumefactive lesion presumed to be reactive in nature. To our knowledge, association with a true neoplasm has not been previously reported. We recently encountered the case of a 67-year-old woman who underwent resection of an incidentally discovered cerebellar cystic mass with a distinct, calcified component. Histology demonstrated...
Hypoxia inducible factor 1α (HIF-1α) is a key regulator of cellular oxygen homeostasis. However, the regulation of HIF-1α in neonates with hypoxia–ischemia (HI) is not clear. Under normoxic conditions, the extracellular signal-related protein kinase (ERK) pathway has been shown to be involved in the activation of HIF-1α in cell lines. Therefore, we hypothesized that the ERK pathway is involved in...
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