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Die Caspase-1 stellt einen integralen Regulator des angeborenen Immunsystems dar, deren zentrale Funktionen die Prozessierung und Sekretion der Zytokine IL-1β und IL-18 sowie die Initiierung des proinflammatorischen Zelltodes Pyroptose sind. Die physiologische Aktivierung der Caspase-1 spielt eine entscheidende Rolle im Rahmen der Immunabwehr des angeborenen Immunsystems. Eine überschießende, dysregulierte...
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