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Purpose. Our aim was to develop an optimal sampling strategy for the description of the pharmacokinetics of rubitecan and its active metabolite 9-aminocamptothecin (9-AC) for use in phase II/III studies with oral rubitecan administered in a daily times five schedule. Methods. Concentration-time data of rubitecan and 9-AC were obtained from 14 patients who had received 1.5mg/m2 per day rubitecan orally...
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