Annals of Hematology

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Methylenetetrahydrofolate reductase C677T polymorphism in adult patients with lymphoproliferative disorders and its effect on chemotherapy

A. Timuragaoglu, S. Dizlek, N. Uysalgil, O. Tosun, more

Annals of Hematology > 2006 > 85 > 12 > 863-868

Methylenetetrahydrofolate reductase (MTHFR) is one of the most critical enzyme in folic acid metabolism, and it converts 5,10-MTHF to 5-MTHF. 5,10-MTHF is required for conversion of uridilate to thymidylate. On the other side, MTHFR enzyme causes methylation of homocysteine into methionine, leading to methylation of DNA. Chemotherapeutic agents have different effects, but DNA is the target for most...

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The significance of the hemochromatosis genetic variants in multiple myeloma in comparison to that of myelodysplastic syndrome

Judit Várkonyi, Judit Demeter, Attila Tordai, Hajnalka Andrikovics

Annals of Hematology > 2006 > 85 > 12 > 869-871

The clinical experience of the significant difference in iron metabolism between multiple myeloma and myelodysplasia prompted us to analyse patients according to mutation frequency in the hemochromatosis gene (HFE) known to participate in the regulation of iron metabolism. HFE genotyping results were also evaluated in view of the clinical data in multiple myeloma (MM) patients. 49 patients with MM...

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Iron prophylaxis in pregnancy—general or individual and in which dose?

Nils Milman

Annals of Hematology > 2006 > 85 > 12 > 821-828

Iron is mandatory for normal fetal development, including the brain. Iron deficiency may have deleterious effects for intelligence and behavioral development. It is important to prevent iron deficiency in the fetus by preventing iron deficiency in the pregnant woman. Iron deficiency anemia during pregnancy is a risk factor for preterm delivery and low birth weight. In the Western countries there is...

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Intervertebral disc calcification in a sickle cell thalassemia patient

M. Kati, M. Tsironi, I. Meletis, D. Farmakis, more

Annals of Hematology > 2006 > 85 > 12 > 875-877

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Copper deficiency pancytopenia with infectious complications after hemolytic anemia

Takayuki Saitoh, Takafumi Matsushima, Kohtaro Toyama, Aarito Yamane, more

Annals of Hematology > 2006 > 85 > 12 > 881-882

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Isolated anterior chamber relapse in acute lymphoblastic leukemia

Rahul Naithani, Neerja Agrawal, M. Mahapatra, Rajat Kumar, more

Annals of Hematology > 2006 > 85 > 12 > 889-891

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Is β-thalassemia trait a risk factor for developing depression in young adults?

Vahid Emad Marvasti, Pooya Dastoori, Mehran Karimi

Annals of Hematology > 2006 > 85 > 12 > 873-874

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Fluorescence in situ hybridization using the subtelomeric 11q probe as a diagnostic tool for congenital thrombocytopenia

G. Göhring, C. Hanke, C. Kratz, U. Kontny, more

Annals of Hematology > 2006 > 85 > 12 > 883-885

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Persistent polyclonal B-cell lymphocytosis: a case report

Dick L. D. Haan, Jos G. J. Pouwels

Annals of Hematology > 2006 > 85 > 12 > 893-896

An erratum to this article can be found at http://dx.doi.org/10.1007/s00277-006-0236-8

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Identification of α-thalassemia mutations in subjects from Eastern Sicily (Italy) with abnormal hematological indices and normal Hb A2

Chiara Bella, Carmelo Salpietro, Mariangela Rosa, Caterina Cuppari, more

Annals of Hematology > 2006 > 85 > 12 > 829-831

We analyzed the prevalence of α-thalassemia mutations in 298 subjects from Eastern Sicily (Italy) with reduced mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH), normal HbA₂ and HbF, and normal serum iron. In 131 subjects (43.9%) we found six different genotypes of α-thalassemia: -α^3.7/αα (36.6%), -α^3.7/-α^3.7 (27.5%), –^MED/αα (10.0%), -α^20.5/αα (9.1%), α^HphIα/αα (8.4%), α^HphIα/α^HphI...

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Polyclonal IgG4 hypergammaglobulinemia associated with plasmacytic lymphadenopathy, anemia and nephropathy

Emmanuelle Boulanger, Vincent Fuentes, Véronique Meignin, Béatrice Mougenot, more

Annals of Hematology > 2006 > 85 > 12 > 833-840

Marked polyclonal immunoglobulin (Ig)G4 hypergammaglobulinemia has exceptionally been reported. Here we report on two Algerian patients who presented a syndrome characterized by anemia, plasmacytic lymphadenopathy, renal manifestations, and a marked polyclonal IgG4 hypergammaglobulinemia leading to a hyperviscosity syndrome in one case. The IgG4-expressing cell percentage was significantly increased...

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Stage-related changes in functional capacity in Hodgkin’s disease: assessment by cardiopulmonary exercise testing before initiation of treatment

Eric Page, David Assouline, Catherine Durand, Odile Brun, more

Annals of Hematology > 2006 > 85 > 12 > 857-861

Our aim was to examine indices of cardiorespiratory capacity at rest and during exercise before initiation of therapy for Hodgkin’s disease. We prospectively studied 24 patients divided into two groups according to the disease stage. Group 1 included eight patients in stage IA and four in stage IIA; group 2 included four patients in stage IIB, six in stage III, and two in stage IV. All patients underwent...

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Not all imatinib resistance in CML are BCR-ABL kinase domain mutations

Yuan Wei, Mats Hardling, Bob Olsson, Rahil Hezaveh, more

Annals of Hematology > 2006 > 85 > 12 > 841-847

Point mutations within the ABL kinase domain of the BCR-ABL gene are associated with clinical resistance to imatinib mesylate in chronic myeloid leukemia (CML). To obtain more information about the association between BCR-ABL mutations and type of imatinib resistance, we studied 30 early chronic phase (CP) CML patients, commencing imatinib therapy, using a conventional sequencing technique. Seven...

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Graves’ ophthalmopathy after allogeneic stem cell transplantation

Charmaine Hon, Kin Yau, Eric Y. T. Chan, Ka-kui Lee, more

Annals of Hematology > 2006 > 85 > 12 > 887-888

article

A single-center study of treatment outcomes and survival in patients with primary gastric lymphomas between 1990 and 2003

Barbara Jezeršek Novaković, Marjeta Vovk, Tanja Južnič Šetina

Annals of Hematology > 2006 > 85 > 12 > 849-856

Primary gastric lymphomas are the most common extranodal non-Hodgkin’s lymphomas and are divided into indolent (low grade) and aggressive (high grade) types. They are mainly the disease of middle age, with a male predominance reported by most of the studies. For several years, surgery played a central role in diagnosis, staging, and treatment of this entity, yet recently there has been a move away...

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A novel missense mutation in glucose-6-phosphate dehydrogenase gene causing chronic nonspherocytic hemolytic anemia in an Indian family

Eunice Sindhuvi Edison, Sameer R. Melinkeri, Mammen Chandy

Annals of Hematology > 2006 > 85 > 12 > 879-880

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Annals of Hematology

Methylenetetrahydrofolate reductase C677T polymorphism in adult patients with lymphoproliferative disorders and its effect on chemotherapy

The significance of the hemochromatosis genetic variants in multiple myeloma in comparison to that of myelodysplastic syndrome

Iron prophylaxis in pregnancy—general or individual and in which dose?

Intervertebral disc calcification in a sickle cell thalassemia patient

Copper deficiency pancytopenia with infectious complications after hemolytic anemia

Isolated anterior chamber relapse in acute lymphoblastic leukemia

Is β-thalassemia trait a risk factor for developing depression in young adults?

Fluorescence in situ hybridization using the subtelomeric 11q probe as a diagnostic tool for congenital thrombocytopenia

Persistent polyclonal B-cell lymphocytosis: a case report

Identification of α-thalassemia mutations in subjects from Eastern Sicily (Italy) with abnormal hematological indices and normal Hb A2

Polyclonal IgG4 hypergammaglobulinemia associated with plasmacytic lymphadenopathy, anemia and nephropathy

Stage-related changes in functional capacity in Hodgkin’s disease: assessment by cardiopulmonary exercise testing before initiation of treatment

Not all imatinib resistance in CML are BCR-ABL kinase domain mutations

Graves’ ophthalmopathy after allogeneic stem cell transplantation

A single-center study of treatment outcomes and survival in patients with primary gastric lymphomas between 1990 and 2003

A novel missense mutation in glucose-6-phosphate dehydrogenase gene causing chronic nonspherocytic hemolytic anemia in an Indian family

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