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Purpose [18F]Fluorocholine ([18F]FCH) was developed as an analog of [11C]choline for tumor imaging; however, its metabolic handling remains ill defined. In this study, the metabolism of [18F]FCH is evaluated in cultured 9L glioma cells and Fisher 344 rats bearing 9L glioma tumors. Methods 9L glioma cells were incubated with [18F]FCH and [14C]choline under normoxic and hypoxic (1% O2) conditions...
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