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Starting from a single generic limit value, the threshold of toxicological concern (TTC) concept has been further developed over the years, e.g., by including differentiated structural classes according to the rules of Cramer et al. (Food Chem Toxicol 16: 255–276, 1978). In practice, the refined TTC concept of Munro et al. (Food Chem Toxicol 34: 829–867, 1996) is often applied. The purpose of this...
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