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Histological and histochemical alterations in the liver and kidneys of the frog Rana ridibunda, which was exposed to 200 ppm aqueous solutions of cadmium for 4, 10 and 30 days, respectively were investigated. In both the liver and kidneys, essential changes appeared after 10 days’ exposure, the maximum changes being apparent after 30 days of exposure. In the liver, what was very characteristic was...
Acetaminophen-induced toxicity has been attributed to cytochrome P-450-generated metabolites, which covalently modify target proteins. However, the mechanism of liver injury pathogenesis needs to be further elucidated. Platelet-activating factor (PAF) is one of the mediators involved in inflammatory tissue alterations associated with acute liver failure. In this study, alterations in blood PAF levels...
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