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Alemtuzumab ist ein humanisierter monoklonaler Antikörper, der an das Zelloberflächenantigen CD52 bindet. CD52 wird auf einer Vielzahl von Zellen der lymphomonozytären Zellreihe exprimiert, nicht jedoch auf Vorläuferzellen. Alemtuzumab führt zu einer raschen und langanhaltenden Depletion von CD52-tragenden Zellen aus dem Blut. In deren Folge kommt es zu einer schrittweisen Rekonstitution, wobei anfangs...
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