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Abstract:Objective and design: To investigate the effect of nitric oxide (NO) donors on inflammatory mouse paw edema (MPE). Materials and methods: Mice previously treated with sodium nitroprusside (SNP; 1.5, 5 and 10 mol/kg) or S-nitroso-N-acetyl-DL-penicillamine (SNAP; 7, 14 and 28 mol/kg) were injected with inflammatory mediators in the paw. Paw edema, myeloperoxidase activity and vascular dye leakage...
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