Introduction. Renal replacement therapy performed as part of dialysis among patients allows replacing the work of their renal failure. However, due to the aggravating nature of this method of treatment, it significantly affects the modification of patients' quality of life. Aim. The purpose of research in this study was to verify selected aspects of the life of hemodialysis patients using a hemodialysis catheter and – venous arteriovenous fistula. Material and methods. The studies were conducted among 100 patients undergoing hemodialysis. They used the diagnostic survey method, estimation method, techniques: survey and estimation scale, and the WHOQOL - BREF questionnaire with the proprietary record. Results. Research results indicate a varied level of quality of life for hemodialysis patients in different domains of their functioning. Conclusions. Most hemodialysis patients present an average level of satisfaction with the quality of their lives. They perceive the individual, general perception of quality of life better than the individual general perception of their own health. The quality of life of patients undergoing hemodialysis does not depend significantly on their age, education and place of residence. Significantly higher assessment of the quality of life within the environmental domain was presented by persons in relationships, the lowest assessment within the social domain was made by widows / widowers. The quality of life of patients undergoing hemodialysis does not depend significantly on the cause, method and time of renal replacement therapy.