Introduction. Schizophrenia is a mental illness characterized by a varied picture and clinical course, characterized primarily by disturbances in thinking and perception, as well as maladjusted and shallow affect. The etiopathogenesis is not fully known, one of the accepted theories is the involvement of biopsychosocial factors, including stress. The age of onset usually falls in early adulthood - for women it is 25–34 years of age, and for men 15–24 years of age. The aim. The aim of the research was to assess the quality of life in the context of the life domains of patients with schizophrenia. Materials and methods. The study included a group of 100 patients treated at Szpital Lipno Sp. z o.o. who have been diagnosed with schizophrenia. The age of the respondents ranged from 18–75 years. The research tool was the SQLS-R4 questionnaire (Schizophrenia Quality of Life Scale Revision 4) extended with an original certificate. Results. The respondents, making a subjective assessment of the quality of life, described it as satisfactory. The quality of life in the vital sphere was higher than in the psychosocial domain and in general satisfaction Conclusions. Schizophrenia is a disease that significantly contributes to the reduction of the quality of life, mainly in the psychosocial domain.