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An extraordinary attention is dedicated to the evaluation of fatigue damage and technical life of different technical systems all over the world because breakdowns caused by a fatigue failure have often a nature of catastrophe. Material fatigue of parts of technical means in critical infrastructure (particularly oversized systems and technological devices) belongs to the most frequent causes of boundary states rise and relating operation breakdowns. Paper contains general formulation of reliability and safety of technical systems judging, brief characteristic of basic areas to be taken in account as input into calculated prediction of technical systems fatigue damage and analysis of risk items by its practical application on a transport means in real working conditions.