The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Magnetic particle imaging (MPI) is a relatively new imaging modality that images the spatial distribution of superparamagnetic iron oxide nanoparticles administered to the body. In this study, we use a new method based on Alternating Direction Method of Multipliers (a subset of Augmented Lagrangian Methods, ADMM) with total variation and l1 norm minimization, to reconstruct MPI images. We demonstrate...
Alzheimer's disease (AD) and its early stage, mild cognitive impairment (MCI), have been widely analyzed by brain functional connectivity network (BFCN) due to its promising potential in identifying biomarkers for the neurodegenerative disorders and understanding the brain functions. The accurate construction of biologically meaningful brain network plays an essential role in these applications. Sparse...
Ultrasound speckle tracking provides a robust motion estimation of fine tissue displacements along the beam direction. Extensions to 2-D have been proposed in recent years. Due to relatively coarse lateral sampling, several solutions relied on lateral interpolation in order to achieve subsample accuracy. We introduce a new multi-dimensional speckle tracking method (MDST) with subsample accuracy in...
Microtubules play an essential role in many cellular processes whose disrupted functioning is associated with devastating human diseases such as cancer. The discovery and testing of microtubule targeting drugs often involve time-lapse fluorescence microscopy imaging of microtubule plus-end binding proteins and require highly accurate estimation of their dynamic behavior. Although many methods exist...
We present a modification to time-delay and phase-shift estimators used in ultrasound imaging methods. In this modification, we selectively eliminate covariance terms from the estimator corresponding to channel signal pairs that have low coherence. We demonstrate this modification in simulation and phantom experiments in the application of color flow imaging. We demonstrate this technique in application...
We present the largest population-based heritability study of the human brain structural connectome, including a pathology-sensitive extension, the disconnectome. The disconnectome maps the effect of white matter lesions throughout the brain. The connectome and disconnectome were generated from diffusion-weighted images of 3255 unrelated subjects from the Rotterdam Study aged between 45 and 99 years...
Cervical nuclei carry substantial diagnostic information for cervical cancer. Therefore, in automation-assisted reading of cervical cytology, automated and accurate segmentation of nuclei is essential. This paper proposes a novel approach for segmentation of cervical nuclei that combines fully convolutional networks (FCN) and graph-based approach (FCNG). FCN is trained to learn the nucleus high-level...
High-throughput serial histology imaging provides a new avenue for the routine study of micro-anatomical structures in a 3D space. However, the emergence of serial whole slide imaging poses a new registration challenge, as the gigapixel image size precludes the direct application of conventional registration techniques. In this paper, we develop a three-stage registration with multi-resolution mapping...
The evolutionary success of ants and other social insects is considered to be intrinsically linked to division of labor and emergent collective intelligence. The role of the brains of individual ants in generating these processes, however, is poorly understood. One genus of ant of special interest is Pheidole, which includes more than a thousand species, most of which are dimorphic, i.e. their colonies...
Osteoarthritis is a common cartilage disease, particularly in societies with aging population. Over 80% of the people over 75 years are affected in the USA. MRI and X-ray can be used to image cartilage, but both approaches suffer from specific drawbacks. X-ray Talbot-Lau interferometers (TLI) have the potential to unite benefits from both modalities. However, TLI setups require to be carefully designed...
We propose a convolutional sparse dictionary learning and coding approach for detecting and counting instances of a repeated object in a holographic lens-free image. The proposed approach exploits the fact that an image containing a single object instance can be approximated as the convolution of a (small) object template with a spike at the location of the object instance. Therefore, an image containing...
This study aims to investigate the apparent backscatter of cancellous bone from the second ultrasonic harmonics using an imaging system. A cylinder model was used as the bone trabecular model and a positive correlation was found between the power spectrum of the second harmonics and trabecular thickness. The result of the in vitro experiment using ultrasound imaging system shows that the apparent...
Hyperechogenicity of the substantia nigra (SN) in the “butterfly shaped” midbrain is a widely recognized diagnostic marker to differentiate between the early stages of Parkinsons Disease (PD) and other diseases which cause parkinsonian symptoms. While clinical differentiation of these diseases can be difficult, hyperechogenicity of the SN is only common in PD patients. Transcranial B-mode Ultrasound...
Three dimensional Polarized Light Imaging (3D-PLI) is a contrast-enhancing technique that measures the spatial fiber architecture in the human postmortem brain or heart at a submillimeter resolution. In a voxel, the 3D fiber orientation is defined by the direction angle and the inclination angle whose sign is unknown. To have an accurate explanation of fiber orientation, it is compulsory to clear...
Mitigating the effects of the twin image artifact is one of the key challenges in holographic lens-free microscopy. This artifact arises due to the fact that imaging detectors can only record the magnitude of the hologram wavefront but not the phase. Prior work addresses this problem by attempting to simultaneously estimate the missing phase and reconstruct an image of the object specimen. Here we...
In medical imaging, images are usually evaluated by a human observer (HO) depending on the underlying diagnostic question which can be a time-demanding and cost-intensive process. Model observers (MO) which mimic the human visual system can help to support the HO during this reading process or can provide feedback to the MR scanner and/or HO about the derived image quality. For this purpose MOs are...
Scanning acoustic microscopy (SAM) is a well-accepted imaging modality for forming quantitative, two-dimensional maps of acoustic properties of soft tissues at microscopic scales. The quantitative maps formed using our custom SAM system using a 250-MHz single-element transducer have a nominal resolution of 7 µm, which is insufficient for some investigations. To enhance spatial resolution, a SAM system...
Automatic non-invasive assessment of hepatocellular carcinoma (HCC) malignancy has the potential to substantially enhance tumor treatment strategies for HCC patients. In this work we present a novel framework to automatically characterize the malignancy of HCC lesions from DWI images. We predict HCC malignancy in two steps: As a first step we automatically segment HCC tumor lesions using cascaded...
The onset and progression of immune-mediated inflammatory arthritis, such as rheumatoid arthritis and spondyloarthritis, are linked to the IL23-IL17 immune axis, so that many therapeutic strategies aim at modulating this pathway. However, there is so far no possibility of an in vivo direct monitoring, without a biopsy, of the specific T cells involved in this modulation. Synovial perfusion, and thus...
In the context of ultrasound (US) deformation imaging it has been shown that lateral motion estimation can be improved by simultaneously combining transverse oscillation (TO) beamforming with dedicated motion estimators and regularisation techniques. This paper provides insights into the relative contributions of beamforming strategies (focused imaging [FOC], plane wave TO beamforming [PWTO], and...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.