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Alzheimer's disease (AD) and its early stage, mild cognitive impairment (MCI), have been widely analyzed by brain functional connectivity network (BFCN) due to its promising potential in identifying biomarkers for the neurodegenerative disorders and understanding the brain functions. The accurate construction of biologically meaningful brain network plays an essential role in these applications. Sparse...
Quantitative medical imaging often utilizes intensity normalization based on a signal from a neighboring region. The choice of this region can substantially affect the quantification, and is potentially confounded by the presence of pathology or other limitations such as partial volume effect. In this paper we outline the desirable list of criteria for selecting a normalization region of interest,...
Automated segmentation of brain structures from MR images is an important practice in many neuroimage studies. In this paper, we explore the utilization of a multi-view ensemble approach that relies on neural networks (NN) to combine multiple decision maps in achieving accurate hippocampus segmentation. Constructed under a general convolutional NN structure, our Ensemble-Net networks explore different...
Cortical thickness estimation performed in vivo via magnetic resonance imaging (MRI) is an important technique for the diagnosis and understanding of the progression of Alzheimer's disease (AD). Directly using raw cortical thickness measures as features with Support Vector Machine (SVM) for clinical group classification only yields modest results since brain areas are not equally atrophied during...
In this work, we study the extent to which structural connectomes and topological derivative measures are unique to individual changes within human brains. To do so, we classify structural connectome pairs from two large longitudinal datasets as either belonging to the same individual or not. Our data is comprised of 227 individuals from the Alzheimers Disease Neuroimaging Initiative (ADNI) and 226...
In clinical practice, the magnetic resonance imaging (MRI) is a prevalent neuroimaging technique for Alzheimer's disease (AD) diagnosis. As a learning using privileged information (LUPI) algorithm, SVM+ has shown its effectiveness on the classification of brain disorders, with single-modal neuroimaging samples for testing but multimodal neuroimaging samples for training. In this work, we propose to...
Accurate registration plays a critical role in group-wise functional Magnetic Resonance Imaging (fMRI) image analysis, as spatial correspondence among different brain images is a prerequisite for inferring meaningful patterns. However, the problem is challenging and remains open, and more effort should be made to advance the state-of-the-art image registration methods for fMRI images. Inspired by...
In order to improve the preclinical diagnose of Alzheimer's disease (AD), there is a great deal of interest in analyzing the AD related brain structural changes with magnetic resonance image (MRI) analyses. As the major features, variation of the structural connectivity and the cortical surface morphometry provide different views of structural changes to determine whether AD is present on presymptomatic...
In this paper a hierarchical brain segmentation from multiple MRIs is presented for a global-to-local shape analysis. The idea is to group voxels into clusters with high within-cluster and low between-cluster shape relations. Doing so, complementing voxels are analysed together, optimally wheeling the power of multivariate analysis. Therefore, we adapted hierarchical spectral clustering to volumetric...
In the recent years there have been a number of studies that applied deep learning algorithms to neuroimaging data. Pipelines used in those studies mostly require multiple processing steps for feature extraction, although modern advancements in deep learning for image classification can provide a powerful framework for automatic feature generation and more straightforward analysis. In this paper,...
This paper presents a novel longitudinal framework for clinical score prediction in Alzheimer's disease (AD) diagnosis. In contrast to the previous approaches that use the data collected at a single time point only for the clinical score prediction, we propose to exploit the imaging data of multiple time points. Furthermore, a spatial-temporal group sparse method is proposed for robust feature selection...
Neurodegenerative pathologies, such as Alzheimer's disease, are linked with morphological alterations and tissue variations in sub-cortical structures which can be assessed from medical imaging and biological data. In this work, we present an unsupervised framework for the classification of Alzheimer's disease (AD) patients, stratifying patients into four diagnostic groups, namely: AD, early Mild...
Optimal representations of the genetic structure underlying complex neuroimaging phenotypes lie at the heart of our quest to discover the genetic code of the brain. Here, we suggest a strategy for achieving such a representation by decomposing the genetic covariance matrix of complex phenotypes into maximally heritable and genetically independent components. We show that such a representation can...
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