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Activated macrophages constitute key players in the development of inflammatory disease such as osteoarthritis. Treatment of inflammatory disorders using peptide drugs may be effective by promoting anti-inflammatory effects. However, poor bioavailability and potential peptide antigenicity may result in unwanted immune responses thus limit its commercial applications. Therefore, in order to improve...
In this paper we present a novel, multiplex, portable microfluidic biosensor for real-time detection and quantification of biomolecules, such as proteins, antibodies, DNA strands and anti-cancer drugs conjugated with Fe3O4 nanoparticles. We show that quantification hands-on time is reduced, and sample throughput can be increased using automation and efficient data evaluation with the appropriate LabVIEW...
Water consumption is vital to human survival. In the past, being able to accurately and easily track water consumption would not have been a viable possibility. The SmartBottle makes this type of tracking possible. It may not be vital to most of us to know how much water we consume on a daily basis down to the milliliter, but there are several medical conditions which require this type of precision...
This paper presents the design, fabrication, and testing of a wireless heart rate (HR) monitoring device based on photoplethysmography (PPG) and smart devices. PPG sensors use infrared (IR) light to obtain vital information to assess cardiac health and other physiologic conditions. The PPG data that are transferred to a computer undergo further processing to derive the Heart Rate Variability (HRV)...
Deep brain stimulation (DBS) surgery involves placing an electrode in the subthalamic nucleus to suppress the motor symptoms, such as tremor, of patients with Parkinson's disease (PD). Currently physicians use the standard Unified Parkinson's Disease Rating Scale (UPDRS) to describe the tremor intraoperatively and post operatively. This scale involves subjective anchor-based observations by the clinical...
There is currently no method for assessing the nature of the cell niche provided by 3D biomaterial scaffolds. Analyzing human bone marrow stromal cell (hBMSC) 3D cell shape in response to different biomaterial scaffolds allowed the 3D cell niche promoted by biomaterial scaffolds to be evaluated. Primary hBMSCs (p5) were seeded (5,000 cells/cm2) in 10 different biomaterial scaffolds and cultured for...
The purpose of this investigation was to determine fibroblast behavior after implantation of ultra-high molecular weight polyethylene (UHMW-PE) rinsed with saline (control) or coated with poly-L-lysine (PLL), arginine-glycine-aspartic acid (RGD), or arginine-glycine-glutamic acid (RGE) into 16 adult male rats subcutaneously. At 90 days post-implantation, fibroblast counts were highest in the saline...
A number of nanoparticles are being investigated as carriers for chemotherapeutics. Unfortunately, these particles are limited by their ability to only transport one drug into the body. The goal of this project was to devise a method for facilitating the addition of a secondary drug. Layer-by-Layer self-assembly using polyelectrolytes encased a secondary drug to the surface of halloysite clay nanotubes...
Pheochromocytomas are rare catecholamine-secreting tumors from the chromaffin cells of the adrenal system. The incidence of pheochromocytoma is approximately 2 to 8 per 1,000,000 individuals. Frankel F in 1886, first described Paragangliomas (PGLs) as extra-adrenal chromaffin cell tumors. Common extra-adrenal sites of tumor include bone, lungs, abdominal organs and lymph nodes. 15% to 35% of paragangliomas...
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