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The bioactive and degradable 70poly(50lactic-co-50glycoric acid)/30(60SiO2-40CaO) composite, which had a dual pore structure, was synthesized by a gas expansion method. The bioactive 60SiO2-40CaO powders were prepared through a sol-gel method from tetraethyl orthosilicate and calcium nitrate tetrahydrate under nitric acidic condition followed by the heat treatment at 900oC for 1 h. The 70poly(50lactic-co-50glycoric...
This paper describes the use of artificial neural networks in predicting value and position maximal wall shear stress in aneurysm. For the purpose of neural network training, back propagation algorithm was used. Input data in the network are geometric parameters of aneurysm model. Obtained results indicate the possibility of a successful application of neural networks in the problems of predicting...
3-Hydroxyphenylacetic acid (3-HPA) is one of the colon microbial metabolites of flavonoids produced in high concentrations (∼300 μM). In this work potency of direct inactivating of selected set of free radicals by 3-HPA was computationally investigated. All calculations were carried out using M05-2X functional with 6-311++G(d, p) basis set coupled with the SMD solvation model. Thermodynamics of three...
Hybrid imaging combining CT and SPECT is becoming a state of the art nuclear medicine technique. Advantages of hybrid imaging are improved quality of the images using CT data for attenuation correction based on true transmission density data in an individual patient, and CT and SPECT fusion images providing accurate localization of the tracer uptake. Accurate localization of increased tracer uptake...
In this report we summarize computational models for convective and diffusive drug transport within small blood vessels (capillaries) and tissue. The presented methodology is primarily focused on drug transport via micro-nanoparticles designed for nanotherapeutics in cancer. Our original multiscale hierarchical models couple nanoscale molecular dynamics (MD) and macroscale continuum finite element...
The aim of this paper is to present the use of the Walsh-Hadamard transform in the analysis of electromygraphic signals representing the uterine contractile activity in pigs. The Fourier spectral analysis is widely used in many biomedical applications. However, for binary time series the Walsh-Hadamard transform based on square or rectangular waves with peaks of ±1 is more accurate. Dominant normalized...
It is fairly established that dynamic recordings of functional activity maps can naturally and efficiently be represented by functional connectivity networks. In this article we study weighted and fully-connected brain networks, created from electroencephalographic (EEG) measurements that concern patients with focal and generalized epilepsy. We introduce a totally new methodology that has never been...
In this paper we present an algorithm that can discriminate between standing and fallen silhouettes in video sequences acquired by a fish-eye camera, in order to detect falls in an indoor environment. The proposed algorithm exploits the model of image formation that is based on the spherical projection to derive the orientation in the image of elongated vertical structures. The algorithm does not...
This paper describes the application of adaptive neuro-fuzzy inference architecture for supporting the diagnosis of lumbar disc herniation. The fuzzy system has been trained with the backpropagation gradient descent method in combination with the least squares method. A total of 38 patients have been divided into training and testing data sets. The performance of the fuzzy model has been evaluated...
This paper aims to highlight importance of coupled thermo-mechanical analysis of structures and devices made of shape memory alloys (SMA). Ti-Ni alloys are recognized as very biocompatible SMA, so theirs usage is very often in medical purpose. Stent implants made of SMA are the best known application of such materials, so the unit cell of some typical stent model is used to demonstrate the necessity...
With limited researches, there is still lack of pathway networks of Chuan-wu (also called Aconitum carmichaelii) against rheumatoid arthritis which might provide clues for further researches. In this study, started from the chemical compounds, proteins targeted by Chuan-wu were explored. After that, pathway networks enriched with these targeted proteins were analyzed with hypergeometric distribution...
Atherosclerosis is a medical condition becoming the number one cause of death worldwide. For this reason, any developement that may help physicians in early diagnostic and selection of the most appropriate treatment strategy is of great importance. In this paper we describe three-dimensional computer model of plaque formation and development for human coronary artery. In order to validate proposed...
Free radical scavenging of gallic acid was studied through electron transfer mechanism (ET) in water and pentylethanoate solutions. Examination was performed using density functional theory (DFT) and Marcus theory. Three particular free radicals were selected for analysis of mechanistic pathway of the second step of sequential proton loss electron transfer (SPLET). Based on the thermochemical and...
Image filtering is one of the most common and important tasks in image processing applications. In this paper, image processing using a mean filtering algorithm combined with thresholding and binarization algorithms for the 3D visualization and analysis of murine lungs is explained. These algorithms are then mapped on the Maxler's MAX2336B Dataflow Engine (DFE) to significantly increase calculation...
We present ePGA (electronic Pharmacogenomics Assistant), a web-based system that offers two main services to the engaged pharmacogenomic biomedical communities namely, explore — a service to search and browse through established pharmacogenomic gene-drug associations, and translate — a service to infer metabolizing phenotypes from individual genotype profiles. Furthermore, we present our work on utilizing...
The development of several biomedical ontologies and databases for structuring and categorizing knowledge in life sciences, and particularly the ones which refer to the functions and interactions of biomolecules, have contributed to the rapid inflation of the semantic information universe that describes cellular complexity, at different scales. Together with the ever-growing number of high-throughput...
Investigation of the motion of deformable particles immersed in fluid is clinically very relevant because it can help to improve treatment planning, diagnostics of disease, design of efficient terapeutical procedures, analysis of drug transport, etc. Experimental investigation of these phenomena is difficult and expensive and, therefore, numerical simulations can contribute to the acquisition of a...
3D heart registration has become an important issue in cardio-vascular diagnosis and treatment. This is mainly due to more accessible medical imaging technologies that can nowadays provide high precision imaging data at relatively lower cost. One of the important features of the heart that has recently drawn attention is epicardial fat (surrounds the heart), which according to some preliminary studies...
This paper will consider a framework for simulation of musculoskeletal system via mass-spring system as the target application. The framework uses a mass-spring systems to simulate the muscle fibres of each muscle and an additional triangle model to visually represent the surface of the muscles. This requires establishing some relationship between the two models so that when some nodes of the mass-spring...
Automatic detection of necrosis in histological images is an interesting problem of digital pathology that needs to be addressed. Determination of presence and extent of necrosis can provide useful information for disease diagnosis and prognosis, and the detected necrotic regions can also be excluded before analyzing the remaining living tissue. This paper describes a novel appearance-based method...
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