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One of the key challenges in osteochondral tissue engineering is to achieve mechanical properties in the engineered tissue that are equivalent to the native tissue. Detailed knowledge of the mechanotransduction pathways occuring in the native tissue is necessary before manipulation towards the aimed properties in the engineered tissue. Purinergic (ATP-mediated) signaling is proving to be one of the...
Misdiagnosis of epilepsy, even by experienced clinicians, can cause exposure of patients to medical procedures and treatments with potential complications. Moreover, diagnostic delays (for 7 to 10 years on average) impose economic burden at individual and population levels. In this paper, a seizure classification framework of epileptic and non-epileptic events from multi-channel EEG data is proposed...
Biomedical signals (BSs), which give information about the normal condition and also the inherent irregularities of our body, are expected to have non-stationary character due to the time-varying behavior of physiological systems. The Fourier transform and the short time Fourier transform are the widely used frequency and time-frequency analysis methods for extracting information from BSs with fixed...
One of the approaches that could be used for cancer treatment is electroporation. This is a relatively new technique and thus its effect on various cancer cell types should be analyzed in detail. In this paper numerical simulations are used, in order to model the behavior of cells after electroporation. Fitting procedure was used for estimation of the parameters of the computer model. This model enables...
In studies so far have been shown that clinical analysis of the gait parameters is extremely important for improving diagnostics and following illness or deficiencies of lower extremities, as well as for analyzing recuperation levels after therapy. Purpose of this paper is to analyze possibility of using easily affordable web cameras for recording knee movement. Recordings are made with web cam on...
Alizarin is anthraquinone with moderate antioxidative capacity. In this work mechanisms of antioxidative activity of alizarin with hydroperoxy and methylperoxy radicals are investigated. All calculations are carried out using B3LYP-D2 method and 6–311+G(d, p) basis set. It is affirmed based on several parameters that hydroxyl group at position 2 is predominant for antiradical activity. PCET mechanism...
The main purpose of this study is to examine how flow field in aortic dissection is affected by its geometry and flow condition. Two models of DeBakey type I aortic dissection, which involves the entire aorta, were analyzed. Patient-specific geometries were reconstructed, based on Computed tomography (CT) scan images, in order to obtain 3D finite element meshes. Computational fluid dynamics (CFD),...
Electrical stimulation and vibration stimulation are two most investigated interfaces for sending the information to humans. It is well known that change in electrical stimulation is not linearly related to the perception of sensation that humans feel. This paper presents the experiment along with results that investigate the relationship between change in electrical stimulation parameters (e.g. pulse...
In cranial radiotherapy highly accurate tumor localization is required to spare healthy tissue while delivering sufficient dose to the target. Here, marker-less optical tracking can support immobilization devices and monitor head motion. However, recent studies have shown that the spatial registration of the optically generated point cloud to a reference is not robust enough. It may suffer from misalignments...
A finite element model of a whole human head was developed to study sound transmission by bone conducted sound. The model comprises tissues as bone, brain and soft tissues. With this model, the motion of the bone surrounding the inner ear was investigated. This was done by defining an imaginary box encapsulating the inner ear and analyzing the motion of the opposing sides. According to this analysis,...
Transcranial Doppler (TCD) is a widely used, non-invasive, rapid and reproducible monitoring method for observing the condition of middle cerebral artery. Micro embolic signals, which appear in various clinical scenarios such as; carotid stenosis, aortic arch plaques, atrial fibrillation, myocardial infarction, patent foramen ovale and valvular stenosis, can be detected by the analysis of TCD signals...
mHealth is a growing field that enables individuals to monitor their health status and facilitates the sharing of medical records with physicians and between hospitals anytime and anywhere. Unfortunately, smartphones and mHealth applications are still vulnerable to a wide range of security threats due to their portability and weaknesses in management and design. Nevertheless, mHealth users are becoming...
This paper introduces the use of a modified feedforward neural network to cope with the problem of predicting protein functions. Since this kind of classification task is inherently hierarchical, this work proposes the use of two different architectures for the modified feedforward neural network, both mimicking the hierarchical nature of the classes (protein functions) to be predicted. The first...
In most cases, cervical cancer (CxCa) develops as a result of underestimated abnormalities present in cytology via the test Papanicolaou (Pap test). Although it is the sole test that has proved its value for cancer prevention, Pap test is prone to human errors as it is performed via the microscope and requires skilled personnel. Consequently, molecular techniques have emerged in the recent years,...
Cyanidin, as one important plant pigment, was theoretically (at M05-2X/6-311+G(d, p) level of theory) investigated for its ability to scavenge potentially, highly damaging hydroxyl radical. The applied method successfully reproduces the bond dissociation enthalpy (BDE), the ionization potential (IP) and proton affinity (PA). The HAT mechanism is most favorable reaction pathway for antioxidative action...
Restoring vision is no longer impossible as a result of recent advances in neural interfaces. Successful demonstrations of retinal implants motivate the development of more effective visual prostheses. The thalamic Lateral Geniculate Nucleus (LGN) is one potential deep-brain interfacing site for visual prostheses. A main challenge in developing thalamic as well as other visual prostheses is optimizing...
Significant number of muscles can be assumed to be of longitudinal type where the length is much higher than its cross-section. Usual motion of the longitudinal muscles is axial due to its contraction and dilatation. Our aim is to investigate the axial vibration of such muscles. The artificial muscle is formed whose physical model is a clamped-free beam. Characteristics of the muscle material are...
Gene-gene interaction is an important factor to consider in selecting genes in genotype data or microarray expression data for association with diseases. However current definitions of gene-gene interaction are not very clear and accurate. An inequality is proved in this paper and a new definition of gene-gene interaction: conditional independence and redundancy based definition of gene-gene interaction...
Continuous monitoring of an individual's stress levels is essential to manage stress and mental state in an effective way. With increasing ubiquity of wearable heart rate monitors and their unobtrusiveness, HRV (Heart rate variability) derived from heart rate signals has emerged as one of the most relevant parameters for continuous monitoring of stress. In the present work, we have made an attempt...
In medical procedures, needle insertion is a challenging task highly dependent on the surgeon's manual skills. Implanted needles are used for drug delivery, biopsy, delivery of radiation sources, etc. In the named clinical procedures, the accuracy of the needle placement is crucial for patient treatment outcomes. Therefore, we have proposed an automated medical device for needle implantation to eliminate...
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