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Although micro-anastomosis is the most commonly performed procedure for reconnecting two blood vessels through sutures, thrombus formation and subsequently anastomotic failure remains one of the most serious clinical complications. An important stimulus to thrombus formation is the altered hemodynamics with abnormal Wall Shear Stress (WSS) distribution on endothelial cells generated by the presence...
In this work we present the decision support of the EMBalance platform. EMBalance is a platform for the management of balance disorders in terms of diagnosis, treatment and evolution. The EMBalance platform aims to extend existing but generic and currently uncoupled balance modelling activities leading to a multi-scale and patient-specific balance model, which will be incorporated in a Decision Support...
The aim of this study is to investigate the effect of mallear and incudal ligaments to the tympanic membrane and the stapes footplate displacement in a finite element model of the middle ear. Three cases were simulated: one without the ligaments, one including the posterior incudal and the anterior mallear ligaments and one including in addition the superior mallear and incudal ligaments. A maximum...
In this paper we present a method for brain tumor segmentation and assess its performance discussing parameters — complexity of initial conditions that need to be set manually, tumor surface area recognition, and computational time. The methodology includes performing segmentation on computerized tomography (CT) medical images from 37 patients. Furthermore, one approach to user friendly two- and three-dimensional...
In this paper the methodology of vertical jump analysis is presented. Measured results of vertical force during jump are presented. Six subjects (members of "Red star" football club) perform different types of jump (flywheel jump, jump without flywheel, and jump with landing on the left and right foot while vertical ground reaction force is measured using a force plate. One axial load cell...
The independence and the maintenance of the autonomy of the elderly promotes the self-care and the quality of living of the long-lived population. With the aid of Information and Communication Technologies (ICT), KINOPTIM project develops a tele-monitoring solution to be used by the elderly in their home environment in order to reduce the risk of falls by remotely monitoring the mobility of the persons...
Calcium silicate cements (CSC) present numerous properties that favor its use in dentistry. The purpose of this study was to investigate how the addition of soy extract affects porosity and wettability of the CSC. Soy was added to commercially available CSC named Portland cement (Italcementi, Spa Bergamo, Italy) at 10 weight % Pure Portland cement was used as a control material. Particle cement size...
The main objective of the study was to treat Alzheimer's disease (AD) plaques using focused ultrasound (FUS) induced blood brain barrier (BBB) opening with and without delivery of antibodies in a rabbit model for AD. The animal model was achieved by feeding a high cholesterol diet to rabbits for 4 months. A single spherically focused MRI compatible transducer was used which operated at 1 MHz, had...
In this paper, we propose a computationally efficient method to estimate the optimal order of the autoregressive (AR) modeling of electroencephalographic (EEG) signals in order to use the AR coefficients as features for the analysis of EEG signals and the automatic detection of epileptic seizures. The estimation of the optimal AR-order is made using regression analysis of statistical features extracted...
Using methods of molecular modeling, we have derived a universal spatial model of the orange carotenoid protein (OCP) and phycobilisome (PBS) core interaction in process of energy excess dissipation. The protrusion of the phy-cobilin domain (PB) of the core-membrane linker polypeptide (Lcm) forms the interaction site for the OCP central cavity on the PBS core surface. This spatial arrangement has...
An easily performed and objective test of patients fine motor skills would be valuable in the diagnosis of Parkinson's disease (PD). In this study we present a set of automatic methods for quantifying the motor symptoms of PD and show that these automatically extracted features can be used to distinguish PD from other movement disorders causing tremor, namely essential tremor (ET), functional tremor...
The importance of the development of the Primary Care network in a developed country is indisputable high. The increasing pressure for productivity improvement and reduction of costs, requires activities focusing on the control and optimization of care processes improving their efficiency and effectivity. A keystone in such priority is the utilization of several effective and comprehensive processes...
In spite of numerous studies on biomechanics of the mucous membrane supported dentures, satisfactory determination of the mucous membrane loads is still lacking. The aim of this study was to evaluate the effect of different mucosa thickness and resiliency on stress distribution of complete denture using a three-dimensional finite element analysis. A edentulous mandible with complete denture was converted...
In order to facilitate the transfer of our technique of expansion of cord blood hematopoietic cells to the industrial scale, we investigated if our two-step ex vivo expansion cultures can be transformed in one-step cultures. For this purpose, the cultures are initiated with the definitive medium volume and with the cell concentrations proportionally decreased. It turned out that the one-step cultures...
This theoretical contribution provides some important recommendations to evaluate the optical properties of natural polyphenols. UV-Vis absorption spectra can be accurately evaluated using regular hybrid DFT functionals. Non-covalent supramolecular assemblies existing between (anthocyanin) pigments and (phenolic) copigments require dispersion correction (to tackle geometrical features) and long-range...
Heart Failure (HF) is a rapidly increasing cardiovascular chronic disease that affects millions of people globally. Lack of proper management of HF patients increases the risk of frailty and other undesirable effects and contributes to loss of independence. The engagement of the HF patient and all actors related to his/her disease management is critical for empowering the patients in achieving sustainable...
Benign paroxysmal positional vertigo (BPPV) is the most commonly diagnosed vertigo syndrome that affects 15% of older persons. BPPV is characterized by sudden attacks of dizziness and nausea triggered by changes in head orientation, and primarily afflicts the posterior canal. We are modeling human semicircular canals (SSC) which considers the morphology of the organs and the composition of the biological...
Assessment of the risks associated with bone injures is nontrivial because fragility of human bones is varying with aging. Since only a limited number of experiments have been performed on the specimens from human donors, there is limited number of fracture resistance curves available in literature. This study proposes a decision support system for the assessment of bone stress intensity factor by...
The reasons for hearing loss are complex and currently the mechanics are not entirely clear. Outer hair cell (OHC) loss is believed to play an important role. Experimental observations shown that damage on OHCs due to ototoxic acid starts from the outermost row to the innermost row, whereas, loss of OHCs due to intense noise exposure occurs from the innermost row to the outermost row. Inspired by...
Science and technology are ever more frequently used in sports for achieving the competitive advantage. Motion tracking systems, in connection to the biomechanical biofeedback, help in accelerating motor learning. Requirements about various parameters important in real-time biofeedback applications are discussed. Special focus is given on feedback loop delays and its real-time operation. Optical tracking...
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