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Metallic nanostructures give rise to bright and dark plasmon modes, and through their interactions can support a variety of coherent phenomena more typically associated with atomic systems, providing new sensing and energy transfer strategies.
Focus will be where light and patient meet, and improvements yielding better outcomes, by detecting, characterizing and monitoring very small entities (molecules, cells) within the human body, quantitatively, dynamically, and preferably without contrast agents.
There is a pressing clinical need to provide image guidance during surgery. Currently, assessment of tissue that needs to be resected or avoided is performed subjectively leading to a large number of failures, patient morbidity and increased healthcare cost. Because near-infrared (NIR) optical imaging is safe, does not require contact, and can provide relatively deep information (several mm), it offers...
We assess the evolution of the optofluidics during the last decade. We will contrast the progress actually made with the expectations from 10 years ago and highlight some of the unexpected developments that have occurred.
Low-risk bronchoscopy techniques for retrieving biopsy samples for the diagnosis of lung cancer are hampered by low diagnostic yields, and trans-thoracic and surgical approaches carry higher intrinsic risk of complications. We are investigating the use of optical coherence tomography to increase the diagnostic yield and accuracy of bronchial biopsy.
A hand-held probe combining high-resolution reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) within the same optical path was developed and preliminarily tested for assessing skin burns. The preliminary results show that these two optical technologies have complementary capabilities that can help the clinician to more rapidly identify the dermal-epidermal junction, determine...
We demonstrate high-density, multi-level crystallization of a Ge2Sb2Te5 thin film using tightly focused femtosecond laser pulses. The optical reflectivity in each distinct phase states level is characterized for applications in ultra-fast cognitive parallel data processing.
The spin state of the silicon-vacancy centre in diamond and its optical accessibility have so far remained elusive. We here evidence spin-tagged fluorescence through resonant optical access to the electronic spin ½ of the centre.
We present a spectrogram-based timing technique for x-ray free electron lasers (XFELs) that reports x-ray/optical delay below 1 fs RMS error to correct for timing jitter.
We introduce loss-proof shape-invariant nonparaxial accelerating beams that overcome both diffraction and absorption, and demonstrate their use in acceleration of microparticles inside liquids along curved trajectories that are significantly steeper than ever achieved.
We design a new type of “tug-of-war” optical tweezers with lateral pulling forces and demonstrate full control of rod-shaped and asymmetric bacteria, including breaking up adhesive cellular clusters inhabiting aqueous media.
We demonstrate for the first time the assembly of an array of gold particles using a guided-resonance mode of a photonic-crystal slab. The 200nm diameter particles form a triangular lattice with spacing of 1140 nm and exhibit high stability.
In this talk I will review recent progress on Optofluidics at Cornell in three application spaces: mobile and global health, bioenergy, and nanoparticle analysis. Fundamental science will be described as well as routes to commercialization and deployment.
We demonstrate through a unique and novel approach based on holographic imaging the ability to achieve full morphological 3D analysis and 3D visualization of motile cells and their accurate 3D tracking for Lab-on Chip devices.
We propose and investigate a novel hybrid plasmonic rod-dimer/ring (RDR) nanostructure with significantly enhanced near-field at the gap region for its potential on sensing and trapping applications.
We demonstrate an all-fiber optical parametric amplifier for life-science (OPALS) application. Optical amplification of megahertz serial time-encoded amplified microscopy (STEAM) images with a resolution of less than 2 µm is achieved with a 20-dB gain.
The photo-induced collective heating enabled by a plasmonic nanoantenna array is for the first time harnessed for rapid concentration, manipulation and sorting of particles, with high throughput. This work could find application in biosensing, and surface enhanced spectroscopies.
Many radionuclides, upon decay, produce visible light via the Cerenkov effect. This allows radiotracers to be imaged using sensitive optical technologies providing opportunities for in vivo optical molecular imaging using Cerenkov luminescence.
A simple scheme of a compact femtosecond Ti:sapphire laser with synchronized Yb-fiber amplifier pumped by a powerful single tapered diode laser implemented in a combined coherent Anti-Stokes Raman and optical coherence tomography platform is presented.
We present structural and molecular-contrast imaging of mouse brain tumors using photo-thermal optical coherence tomography (PT-OCT) in vivo. Based on strong PT response of gold nanostars, we demonstrate clear visualization of brain cancer margins.
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