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We have used THz absorption spectroscopy as a tool to probe the collective hydration dynamics of ions and proteins. Whereas in bulk water, the hydrogen bonds break and reform every picosecond on average, in the vicinity of solutes like proteins, water molecules show a retardation of hydrogen bonds rearrangement dynamics. We report here THz absorption spectroscopic measurements of anions and ions as...
We studied salt effects on hydration water of protein using terahertz time-domain spectroscopy (THz-TDS). The number of hydration water molecules at the protein surface was observed to decrease by addition of ammonium sulfate, while ammonium thiocyanate increases it.
We use a rapid data acquisition technique to test reproducibility and inhibitor binding sensitivity of the recently reported narrow band resonances for lysozyme protein crystals using THz microscopy. The spectra are reproducible, and change dramatically with inhibitor binding. The results indicate the resonances arise from intramolecular modes.
In this paper we use terahertz spectroscopy to study the concentration dependence non-linear absorption behaviors of the influenza virus hemagglutinin (HA) protein and effects of HA protein interacting with the neutralization antibody in the solutions. The thickness of the hydration shell around the HA protein was determined based on two and three components model. The absorption coefficient was measured...
This study addresses the analysis of THz absorption spectra of solvated biomolecules. Simulation results of tryptophan cage (TRP-cage) protein solvation dynamics are obtained using the molecular dynamics package, Gromacs. The relative THz absorbance by the hydration shell around a protein is calculated based on the information related to the dipole auto-correlation function (ACF) and velocity ACF.
Broadband time-domain spectroscopy was used to measure the terahertz frequency absorption of protein single crystals in order to study global protein dynamics. Temperature dependent dynamics were measured for lysozyme, and the terahertz frequency spectrum of mouse urinary protein was compared to calculated spectra.
Temperature- and hydration-dependent terahertz spectra of hen egg white lysozyme were obtained by using terahertz time-domain spectroscopy. Analysis of the complex dielectric spectra indicated hydration-water dynamics at around 2 picoseconds were thermally activated above 230 K upon hydration.
Integrated Terahertz Sensor operating at 0.25THz detects in 4–40 nL volume liquids: biomolecule concentration, conformation, binding and cell physiology. The sensor exhibits State-of-the-Art performance: sensitivity up to 50dB·(g/L)−1 and detection limit down to 9mg/L.
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