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Intramuscular injections are a common medical procedure performed countless times on a daily basis; however the actual procedure of giving an injection is rather complicated and can be intimidating to nursing students new to the medical profession. The instrumented syringe discussed in this paper was conceived as a tool to help train individuals in proper injection procedure and technique. Utilizing...
The project is to build a full-scale working replica of the Twin Coil dialysis device designed by Willem Kolff who introduced this much improved dialysis machine for hospital and clinical use in 1955. The first step was to analyze original models of the Kolff Twin Coil on display in Washington, DC and in Largo, Florida and understand the design and engineering aspects of the device and how the Twin...
Continuous passive separation based on laminar flow and creative geometries has advantages over traditional separation methods such as dielectrophoresis, hydrodynamic chromatography, and acoustic separations to name a few. One advantage in particular is the lack of constant energy supply needed and another advantage is the ability to continuously operate the device for larger sample volumes without...
Thoracic catheters are inserted into patients after thoracic surgery in order to facilitate the removal of fluid and/or air. Though their insertion is common practice, their use is plagued by complications including severe patient pain and occlusion, which can lead to adverse patient outcomes. In order to overcome these complications the authors developed a novel catheter. This design has the existing...
The ability of activated leukocytes to retract pseudopods in response to fluid shear stress may be a critical mechanism to downregulate inflammation and maintain stable circulation. By measuring earlier indicators of leukocyte activation such as L-selectin shedding and β2 integrin activation, which precede morphological changes, we have found that exposure to physiological levels of fluid shear stress...
The purpose of this work is to design novel, modular devices in order to reproduce traumatic brain injury in the rat and mouse models: fluid percussion injury (FPI), controlled cortical impact (CCI) and the Shock tube. Commercially available TBI devices are often unimethodical, expensive and sensitive to experimental variability. To achieve maximum control and sensitivity, in our first device, we...
Biphasic contact of soft tissues is fundamental to understanding the biomechanical behavior of human diarthrodial joints. In this paper, a finite element formulation is developed for 2D axisymmetric contact of biphasic tissues. Augmented Lagrange method is used to enforce the continuity of contact traction and fluid pressure across the contact interface, and implemented in COMSOL Multiphysics. The...
Severe mechanical trauma of the spinal cord induces a secondary injury response that contributes to post injury cell death and the formation of barriers inhibitory to neuronal regeneration. It is believed that engineered scaffolds produce favorable results when they mimic the properties of the tissue that they are aiming to replicate. Alginate hydrogels have been shown to be beneficial in a number...
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