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Mecamylamine, pharmacologically, has been well characterized as a nonselective and noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). Because mecamylamine easily crosses the blood - brain barrier at relatively low doses, it has been used by several research groups over the past two decades investigating the role of central nAChRs in the etiology and treatment of various neuropsychiatric...
AFLP is a PCR-based tool used in genetics research and DNA fingerprinting. Predicting the result and selecting the right primers play key roles in AFLP. Software called AFLP Runner (AR) was developed for AFLP predicting and analyzing. AR is a software based KMP algorithm for finding restriction enzyme cutting site sequence in genome. AR can be used for all organisms' AFLP primers selecting, bands...
Research on gene co-expression not only plays an important role in understanding the complex regulatory relationships, it also contributes to our understanding of gene regulatory networks. In this study, based on ATTED-II database, we identified the Arabidopsis anther genes, and then constructed the co-expressed networks for every anther genes, finally, mined the co-expressed data from these co-expressed...
RPL18A is a component of the 60S large ribosomal subunit encoded by RPL18A gene, which plays an important role in ribosome. To explore the structure characteristic of ribosomal protein L18 (RPL18A) gene of the Giant Panda (Ailuropoda melanoleuca) and the differences with other species reported,we have designed primers which based on the already-known information of RPL18A gene. Then, the cDNA and...
The analysis on codon usage bias of gI gene of duck enteritis virus (DEV) may provide a basis for understanding the evolution and molecular characteristic of DEV, and for selecting appropriate host expression systems to improve the expression of target gene. A comparative analysis of the codon usage bias of the DEV gI gene and 22 other refrence herpesviruses gI-like genes was performed, by using the...
Ribosomal protein L11 (rpL11) which is a component of the 60s large ribosomal subunit plays an important role in ribosome. To explore the structure characteristic of rpL11 gene of the Ailuropoda melanoleuca, we have designed primers based on the known nucleotide sequence of rpL11 gene. The RT-PCR and PCR strategy were employed to isolate cDNA and genome of rpL11 from the Ailuropoda melanoleuca respectively,...
Expressed sequence tag (ESTs) are a technology used for gene discovery and transcriptome analysis. They are single-read short fragments of expressed gene produced from mRNA extracted from a living cell. Clustering is a vital computational step in the processing of ESTs, its main goal is to ensure that all ESTs originated from the same mRNA are grouped together. Basically, the clustering algorithms...
Through the comparative studies of k-mer distribution in Saccharomyces cerevisiae (S.ce) and Schizosaccharomyces pombe (S.po) transcription factor binding site (TFBS) sequences we have discovered that the average distance between a pair of transcription regulatory 7-mer motifs is conservative in S.ce-S.po promoters. The distance conservation is a new kind of evolutionary conservation, not based on...
Repeat regions in DNA play very important roles in many vital biological functions. Repeats finding is always deemed as one of the most fundamental problems in genome sequencing and analysis, and exact repeats finding is the first step for many other repeats finding problems. This paper depicts the design and implementation issues of a fast data parallel short exact repeats finding algorithm on a...
Numerous studies have shown that the myocilin gene (MYOC) plays an important role in primary open-angle glaucoma (POAG) and high myopia. However, little is known about the genetic regulatory network. In this study, we combined array analysis and quantitative trait loci (QTL) mapping approaches (genetical genomics) to characterize the expression variation and the regulatory network of Myoc in the eye...
There is a growing consideration that gene-gene interactions may play important roles in complex diseases etiology. The simultaneous genotyping of hundreds of thousands of single nucleotide polymorphisms (SNP) have provided an excellent chance to study genetic epidemiology from molecular network. In this paper, we performed genome-wide gene-gene interaction associated with rheumatoid arthritis (RA)...
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