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The initial motivation for this work was to accomplish an easy way to manufacture different geometries of ultrasonic transducers and arrays using a PZT powder, combined with a standard process to have repetitive series of them. The piezoelectric thick film was obtained using a PZT paste and applying it by screen printing on an alumina substrate. Then, the film was drying and sintered with a temperature-time...
A 170μW readout IC for a capacitive MEMS acceleration sensor was implemented in a 1.5V 0.13μm CMOS for high-end medical motion sensing applications. The accelerometer achieves a 45μg/vHz noise floor and a dynamic range larger than 87dB for a 400Hz bandwidth. Power reduction is achieved by introducing reset and common-mode feedback circuit techniques based on a non-unity-gain feedback configuration.
Current work is a part of long term research, which aim is to study the possibilities to diagnose the atherosclerosis in early stadium by using pulse wave velocity and its waveform analysis. The mobile experimental measurement complex is built and technically tested for the long term study in hospital. Measurement complex consists of ten physiological signal recording channels and reference devices:...
Nutrition is a critical aspect when getting older because bad nutrition habits can accelerate the process of degradation of the physical condition of the old person. In order to mitigate this problem, an Ambient Assisted Living service has been developed. Research with this service is focused on demonstrating that with an Ambient Intelligence systems it is possible to make the nutritional management...
A patient's sleep/wake schedule is an important step underlying clinical evaluation of sleep-related complaints. Aspects related to timing of a person's sleep routine provide important clues regarding diagnosis and treatments. Solutions for sleep complaints may sometimes rely solely on changes in habits and life style, based on what is learned from daily rest-activity patterns. This paper describes...
Ambient Assisted Living (AAL) is an emerging bundle of technologies and services that has been specially conceived to support disabled and elderly people to be more autonomous in their daily life. Support for mobility is a key aspect in AAL, and makes elderly people feel very independent and socially integrated. This paper describes an AAL solution to support elderly people outside home: provides...
In this paper we discuss about the integration of Ambient-Assisted Living (AAL) with virtual worlds. The integration of sensors from the AAL environment (e.g. vital signs, motion sensors) in the Virtual World can enhance the provision of in-world eHealth services, such as tele-rehabilitation, and taking advance of the social nature of virtual worlds. An implementation of a virtual world integrated...
As the number of seniors with chronic disease increases, the need of home healthcare settop-box is increased to manage their chronic disease in their home environment. Using the home healthcare settop-box, the patients can regularly check their health data, and finally, it can lead the decrease of medical expenses. For the home healthcare settop-box, the most important factor is the standard compatibility,...
In this study, we target to automatically detect behavioral patterns of patients with autism. Many stereotypical behavioral patterns may hinder their learning ability as a child and patterns such as self-injurious behaviors (SIB) can lead to critical damages or wounds as they tend to repeatedly harm one single location. Our custom designed accelerometer based wearable sensor can be placed at various...
Atrial tachycardias are the most common cardiac arrhythmias in clinical practice, which induce changes in atrial properties that help to perpetuate them. These changes are called “atrial remodeling”. Recent studies have shown that rapid ectopic activity principally on the pulmonary veins can trigger reentrant mechanisms and lead to atrial tachycardias. However, the influences of ectopic foci location,...
The cardiac Monodomain model is a mathematical model extensively used in studies of propagation of bioelectric wavefronts in the heart. To be able to use the model for complex and large cardiac simulations, such as the case of whole heart and 3D simulations, some parameters of the model that are known to physiologically vary in space, such as the intracellular conductivity, are traditionally kept...
Model and simulation of biological systems help to better understand these systems. In ICUs patients often reach a complex situation where supportive maneuvers require special expertise. Among them, mechanical ventilation in patients suffering from acuter respiratory distress syndrome (ARDS) is specially challenging. This work presents a model which can be simulated and use to help in training of...
This work proposes a new theoretical framework for the water transport in the cerebral environment. The approach is based on Multiple-Network Poroelastic Theory (MPET) and is a natural extension of poroelasticity, a well reported technique applied to cerebrospinal fluid (CSF) transport. MPET accounts for the transport of CSF and blood simultaneously, as they permeate and deform the cerebral tissue...
We present a reduced order finite element (FE) algorithm suitable for real-time nonlinear simulation of soft tissues. A dynamic FE formulation with explicit time integration is employed. We demonstrate significant computation acceleration by performing the time integration in a low-dimensional generalised basis, generated from a set of a priori training simulations. The key mechanism for the acceleration...
A three-dimensional anatomically and electro-physiologically realistic model of atrial propagation is developed utilizing generic cardiac ionic models fitted to experimentally recorded action potentials (APs). The atrial geometry incorporated realistic wall thickness and twelve anatomical structures, including the sino-atrial node (SAN), pulmonary veins, interatrial septum, Bachmann's bundle and coronary...
Biomaterials have been widely used in reconstructive bone surgery to heal critical-size long bone defects due to trauma, tumor resection, and tissue degeneration. In particular, gelatin cryogel scaffolds are promising new biomaterials owing to their biocompatibility; in addition, the in vitro modification of biomaterials with osteogenic signals enhances the tissue regeneration in vivo, suggesting...
Small calibre (<;;6mm) polytetrafluoroethylene (PTFE) bypass grafts have poor medium and long term patency due to the development of neointimal hyperplasia at the distal anastomosis. The inelasticity of PTFE is implicated in this mechanism of failure. We have developed a novel polyhedral oligomeric silsesquioxane (POSS) nanocage incorporated into a poly(carbonate)urethane (PCU) biomaterial with...
Cardiovascular diseases, specifically myocardial infarction and end-stage heart failure represent some of the major pathologies that threaten human life. Here we present a novel approach for a bioactive cardiac patch based on a combination of biomedical and textile manufacturing techniques in concert with nano-biotechnology based tissue-engineering stratagems. The technological goal is to create BioNanoTextiles™...
Bioprinted tissue test systems show promise as a powerful tool for studying cell-cell interaction in heterogeneous, tissue-like co-culture. Several challenges were encountered while attempting to consistently fabricate samples with high viability and pattern fidelity. This paper evaluates four methods for processing samples after bioprinting but prior to adding media for incubation. These methods,...
This paper describes the basic guidelines for developing an innovative biomedical device. It covers the issues of researching about a suitable material, developing a new device, and testing its proprieties to check its effectiveness. The goal of the device is to control food flow into the esophagus, reducing its volume and the speed of food intake to help in the treatment of obesity. This module,...
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