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Implantation of sensors to measure hemodynamic parameters such as pulsatile pump flow and differential pressure (head) in an implantable rotary pump (IRBP) requires regular in situ calibration due to measurement drift. In addition, risks associated with sensor failure and thrombus formation makes the long-term implantation in patients problematic. In our laboratory, two stable and novel dynamical...
A major concern in human movement research is preventing tripping and falling which is known to cause severe injuries and high fatalities in elderly (>65 years) populations. Current falls prevention technology consists of active interventions e.g., strength and balance exercises, preimpact fall detectors, and passive interventions e.g., shower rails, hip protectors. However it has been found that...
The problem of identifying in advance the most effective treatment agent for various psychiatric conditions remains an elusive goal. To address this challenge, we propose a machine learning (ML) methodology to predict the response to a selective serotonin reuptake inhibitor (SSRI) medication in subjects suffering from major depressive disorder (MDD), using pre-treatment electroencephalograph (EEG)...
Complex diseases may be caused by interactions or combined effects between multiple genetic and environmental factors. One of the main limitations of testing for interaction between genetic loci in large whole genome studies is the high computational cost of performing such analyses. In this study a new methodology for interaction testing (commonly referred to in genetics as the epistatic effect)...
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