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This paper summarizes dynamic measurements of shear modulus constants acquired for spontaneously growing rat mammary tumors. Measurements are compared with histology to determine tumor types. We also report on 3D shear-wave velocity fields acquired from an inhomogeneous hydrogel phantom with known mechanical properties. Phantom measurements enable us to interpret the effects of tissue structure and...
This paper presents a phase-based method for estimating subpixel motion in medical ultrasound imaging. The main novelty is to propose a closed form expression for local motion estimation in space domain based on the model of the monogenic signal. First, the proposed method uses the properties of the monogenic signal in order to extract local orientation and phase data of ultrasound images. Second,...
The early detection of biomechanical modifications in the arterial wall could be used as a predictor factor for various diseases, for example hypertension or atherosclerosis. In this work a transient elastography technique is used for the in vitro evaluation of the arterial wall elasticity. The obtained Young modulus is compared with the one obtained by a more classical approach: pressure-diameter...
An important goal in clinical cardiology is the non-invasive quantification of regional cardiac deformation. While many methods have been proposed for the estimation of 3D left ventricular deformation and strains derived from 4D ultrasound, currently there is a lack of in vivo clinical validation of these algorithms on humans. In this paper, we describe the experiments used in validating cardiac deformation...
Our group has been investigating the use of Shearwave Dispersion Ultrasound Vibrometry (SDUV) for quantifying viscoelasticity of the myocardium. The primary aim of this study is the design and testing of viscoelastic materials suitable for validation of the Lamb wave model in the heart. The Lamb wave SDUV method was used to measure shear wave velocity dispersion of gelatin and urethane rubber plates...
The acoustic radiation force has been used as the method to examine the physical properties of materials in several areas. Vibro-acoustography is an acoustic radiation force technique that is being used to perform analysis of mechanical properties of materials. In this application a focused acoustic modulated force excites target which vibrates at the frequency of modulation. The emitted sound is...
The initial motivation for this work was to accomplish an easy way to manufacture different geometries of ultrasonic transducers and arrays using a PZT powder, combined with a standard process to have repetitive series of them. The piezoelectric thick film was obtained using a PZT paste and applying it by screen printing on an alumina substrate. Then, the film was drying and sintered with a temperature-time...
Obstructive sleep apnea/hypopnea Syndrome (OSAHS) is the most common form of Sleep Disordered Breathing (SDB) and it is estimated to affect approximately 6% of US adult population. Various methods have been proposed for the development of inexpensive screening methods to detect SDB to reduce the need for costly nocturnal polysomnography (NPSG). By using the existing air in the airway as an ultrasonic...
We have already reported our attempt to constrain direction of microcapsules in flow owing to an acoustic radiation force. However, the diameter of capsules was too large not to be applied in vivo. Furthermore, acoustic radiation force affected only in focal area because focused ultrasound was used. Thus we have improved our experiment by using microcapsules as small as blood cells and introducing...
The purpose of this report is to propose portable and attachable tele-echography robot system: FASTele. Focused assessment with sonography for trauma (FAST) is important for patients who have shock by internal bleeding. However, the patient has little time, and transportation to a hospital may take too long. A system which enables FAST more quickly is required. Therefore, we aim to develop a tele-echography...
This work focuses on an infant deafness detector unit, using the concept of microphone array. This instrument is based on the principle of evoked acoustic emissions (OAEs). The key feature of the microphone array is its ability to increase signal-to-noise ratio (SNR) and reproducibility of the OAE responses. These further significantly contribute to improve the sensitivity and specificity of the overall...
In patients with gastroesophageal reflux disease (GERD), esophageal symptoms are traditionally diagnosed by monitoring the contact time between the reflux content and the esophagus using multichannel intraluminal impedance and pH (MII-pH) catheters. However, esophageal catheter for quantifying the volume of reflux content is still lacking. The present work proposes an innovative method to develop...
Navigated ultrasound (US) imaging is used for the intra-operative acquisition of 3D image data during image-guided surgery. The presented approach includes the design of a compact and easy to use US calibration device and its integration into a software application for navigated liver surgery. User interaction during the calibration process is minimized through automatic detection of the calibration...
Acupuncture is used widely in oriental medicine. But it is difficult to stimulate continuously or intermittently in daily life with conventional acupuncture. An acupoint stimulation device using focused ultrasound has been developed. Because the device size is about 6 mm in diameter, it can be easily put on the skin during daily life. Appropriate stimulation intensity and pattern can be chosen by...
The trabecular bones are highly dispersive acoustic media composed by randomly shaped trabeculae (considered as scatterers) and surrounded by bone marrow. An acoustic wave generated by an incident ultrasonic pulse with respect to the media under study, shows that its velocity and amplitude are a function of the density size and shaped of the scatterers. Two different methods were used to theoretically...
Wall artery viscoelastic properties (WAVP) are correlated with structural and functional state of the arterial system. An accurate estimation of these properties is achieved measuring wall instantaneous diameter and pressure signals. The aim of this work was to evaluate a new non invasive estimation method of the instantaneous arterial diameter (D), and consequently, WAVP. Ten common carotid arteries...
Early and accurate detection of asymptomatic emboli is important for monitoring of preventive therapy in stroke-prone patients. One of the problems in detection of emboli is the identification of an embolic signal caused by very small emboli. The amplitude of the embolic signal may be so small that advanced processing methods are required to distinguish these signals from Doppler signals arising from...
Autoregulation refers to the automatic adjustment of blood flow to supply the required oxygen and glucose and remove waste, in proportion to the tissue's requirement at any instant of time. For the brain, cerebral autoregulation is an active process by which cerebral blood flow is controlled at an approximately steady level despite changes in the arterial blood pressure. Robust assessment of the cerebral...
In several clinical and experimental circumstances, it is widely necessary to characterize the bio-mechanical changes induced by atherosclerosis to the arterial wall. In this context, the purpose of this paper is twofold. Firstly, to propose a low cost ultrasound setup to improve artery radii determination in elasticity experiments, based on two transducers using a single channel ultrasound hardware...
Although a variety of factors have been proposed as key factors of the atherosclerotic plaque vulnerability, the mechanisms that contribute to this problem are not yet fully characterized. In previous works we demonstrated that changes in arterial wall viscosity and elasticity and/or in the filtering function (FF) could be in the basis of arterial wall alterations. If these properties are altered...
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