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With a highly sensitive one dimensional photonic crystal biosensor, we have demonstrated quantitative real-time label-free detection of DNA oligomers, including binding to protein, concentration detection limits, and base-mismatched hybridization.
UV-induced optical polymer waveguides and microfluidic channels were integrated on a single polymer chip as a platform for fluorescence excitation of biological samples. Fluorescence excitation could be demonstrated for labeled phospholipids and for stained cells.
We have developed a novel high-resolution molecular imaging technique, Pump-Probe Optical Coherence Microscopy, based on the fusion of Pump-Probe spectroscopy and Optical Coherence Microscopy and demonstrated it on fixed human skin containing a nodular melanoma.
We developed a Finite Element package to analyze cladding mode field extensions into the air-holes of photonics crystal fiber for refractive index sensing. Our analysis could determine the most sensitive cladding mode for liquid sensing.
Aortic valve samples, classified into normal, mild, moderate and severe fibrous calcific tissue based on Raman Spectroscopy, were analyzed with Optical Coherence Tomography. Results point OCT as a powerful diagnostic tool for aortic valve stenosis.
Second and Third harmonic imaging were investigated to observe a corneal flap created by an ophthalmic knife or a microkeratome as it can be processed during a LASIK surgery.
We experimentally demonstrate optical trapping with micro-ring resonators. Tuning the incident wavelength enables controlled trapping and release of particles. The resonance frequency red-shift upon trapping enables monitoring of the particle physical properties.
It is shown that integration of microspheres inside microcapillaries or hollow waveguides allow the development of compact focusing tools for a variety of biomedical and photonics applications.
We generate optical beams with rotating intensity blades, namely “optical propellers”, by employing Moiré technique. Such rotating beams are controlled by SLM without mechanical movement or phase-sensitive interference. Self-trapping of propelling beams is also demonstrated.
We present a novel single cell manipulation platform based on phototransistor optoelectronic tweezers. This new platform integrates the functionalities of phOET for parallel cell manipulation in highly conductive culture media with a commercial microfluidic device.
Azobenzene modified silk, a biocompatible material suitable for applications in biomedicine is shown to display photo-effects such as optically induced birefringence, suitability as a holographic recording material and photoinduction of surface relief features.
We present the integration of two ultra-sensitive technologies - ARROW waveguides and solidstate nanopore - in a planar electro-optofluidic platform. The functionality of the chip is demonstrated using concurrent electrical and optical detection of fluorescent nanospheres.
We report the compact integration of high-power 780-nm VCSEL arrays with a microfluidic channel to create an optofluidic microchip. Characterization of the microchip using a near-infrared fluorescent dye yields a detection limit of 10 µM.
We present a careful investigation of the optical properties of Zr-doped lithium-niobate crystals. We also investigate in detail the threshold concentration for Zr-doping, by means of three different optical measurement techniques.
We introduce phase-sensitive motility contrast imaging and present high-contrast time-course measurements of cytoskeletal anticancer drug effects on dynamic motion inside tumor spheroids obtained by digital holographic optical coherence imaging.
Resonant silicon photonics has recently enabled the direct optical tweezing of nano-objects on chip. Here we present a comprehensive evaluation of different resonator designs and demonstrate one with a stiffness of 22.3 pN nm−1 W−1.
A molecular design strategy that involves favorable control of one- and two-photon absorption resonances to produce exceptional nonlinear optical figures-of-merit for all-optical switching has been realized in a series of cyanines dyes.
We investigated a coherent anti-Stokes Raman scattering microscopy with a single-pass picoseconds supercontinuum-seeded optical parametric amplifier (SCOPA). Our SCOPA system is substantially simpler because the pump and Stokes lasers are automatically overlapped.
A femtosecond laser-microscope system is custom-built for ablation of cells and tissue at 1030 nm. Fiber lasers offer important advantages for nanosurgery, including superior robustness, lower-cost and nearly complete control over pulse train pattern.
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