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We demonstrate a simple method to make high-resolution P-selectin patterns based on microcontact printing for controlling cell rolling. SEM characterization revealed well-defined patterns that could direct the trajectories of rolling HL60 cells along the edges. Cell tracking revealed that velocities of rolling cells were higher at the edges as compared to plain P-selectin regions, with a maximum at...
Macromolecular transport across the vessel wall, apparently the earliest pre-atherosclerotic event, is known to occur due to advection by transmural pressure driven water transport, characterized by the hydraulic conductivity (Lp). Our group's discovery of the presence of aquaporin-1 (AQP) in aortic endothelial cells suggests a new possibility of water transport across the endothelial cell (EC), alongside...
Plasma, mostly water and solutes, advects low-density-lipoprotein (LDL) across the arterial endothelium. Subendothelial LDL deposition triggers pre-artherogenic lesion formation. This water flux is believed to occur paracellularly. We investigate the potential significance of the transcelluar pathway through the ubiquitous aquaporin-1 (AQP1) water channel protein to total transmural water flow. AQP1...
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus, and despite many years of research it continues to be the major cause of blindness in adults. Understanding the molecular mechanisms by which transport across the inner Blood Retinal Barrier (iBRB) is regulated is a key step for the discovery of improved means to control vascular permeability and loss of...
We have previously shown that leaky junctions associated with dying or dividing cells are the dominant pathway for LDL transport under convective conditions, accounting for more than 90% of the transport. To explore the role of apoptosis in the leaky junction pathway, TNF?? and cycloheximide (TNF??/CHX) were used to induce an elevated rate of apoptosis in cultured bovine aortic endothelial cell (BAEC)...
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