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A mathematical model of short-term arterial pressure regulation by the carotid baroreflex was integrated with a simple cardiovascular model to study the interactions between the baroreguation and the pusating heart. The cardiovascular system was modeled as an electric circuit, consisting of the left ventricle as a time-varying capacitance, the systemic circulation as a four-element RLC circuit, the...
Three-dimensional (3D) analysis of the deforming airway during tidal breathing has not been performed in children with obstructive sleep apnea. We used volume-gated magnetic resonance images to segment, surface, and volume mesh the airway of one child with obstructive sleep apnea syndrome (OSAS) and one control. A computational fluid dynamics (CFD) study was performed on each airway at flow rates...
Accurate estimation of food volume plays an important role in dietary assessment using digital photographs. In this paper, we present a new approach based on a circular object (e.g., a dining plate or a coin) as a physical reference to determine food portion size. A geometrical model relating the circular object and its image is built. An algorithm to estimate food volume using the geometric model...
Osteocytes exhibit solid-like viscoelastic behavior in response to mechanical stresses. The goal of this study was to determine the viscoelastic properties of osteocytes using a combined finite element analysis (FE) modeling and experimental approach. The three-dimensional (3D) cell shape of the osteocyte under fluid flow was reconstructed using using a novel pseudo-3D microscopy technique. The cell...
Osseointegration is critical for implant fixation, and mechanical stimuli play a role in this process. Our long term goal is to investigate the relationship between local mechanical environment and osseointegration. In this paper, as a first step in the study, we constructed an approximate 3D model of the in-vivo test and focused on calculating the strain fields around the implant. We first demonstrated...
This study investigated whether manipulated visual feedback can affect neural activations while observing interactions in a virtual environment. Twelve healthy, right-handed subjects performed sequential finger flexions during functional MRI scanning. An MRI-compatible data glove was used to measure joint angles and to animate the movement of virtual hands in real time. Visual feedback of hand movement...
Despite the prevalence of microfluidic-based heterogeneous immunoassays, there is incomplete understanding of analyte capture parameters. This study presents computational results and corresponding experimental binding assays of analyte capture. Our results identify: 1) a ??reagent-limited?? regime, under constraints of finite sample volume and assay time; 2) a critical flow rate; 3) an increase in...
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