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Rosette nanotubes (RNTs) are novel, biomimetic, synthetic, self-assembled drug delivery agents. Because of base stacking and hydrophobic interactions, the RNT hollow-tube structure can be used for incorporating drugs. Another advantage of using RNTs is their ability to be injected and become solid at body temperatures for orthopedic applications without the use of any external stimuli (such as UV...
High speed boat (HSB) crewman in the U.S. navy often suffer from lower back pain and accelerated intervertebral disc (IVD) degeneration, due to the high-G impacts experienced during typical missions, resulting in significant time on limited duty status. The relationship between high impact loads and disc biomechanics is not well understood. We seek to analyze the changes in mechanical behavior, particularly...
As with all surgical procedures, implantation comes with the added risk of infection. The inability of antibacterial therapy to treat persistent infection demonstrates the need for a more advanced therapeutic approach. The goal of this proposal is, for the first time, to use superparamagnetic iron oxide nanoparticles (SPION) to treat infection on biomedical devices. The hypothesis of this study is...
Alterations in the major biochemical constituents of intervertebral discs coincide with aging and degeneration, and can alter the disc's ability to support load. The most significant biochemical change that occurs in degeneration is the loss of proteoglycans in the nucleus pulposus. During a diurnal cycle, the disc experiences approximately 16 hours of functional loading, followed by 8 hours of recovery...
To evaluate scaffolds used for bone repair, composed of HA/??-TCP, in vitro and in vivo. Chemical and mechanical characterization was performed on the bulk material while the in vivo portion was utilized to study host response to the scaffold.
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