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Current delivery systems for vaccines present major logistical problems when large populations need to be vaccinated within a short time period, such as in the case of a pandemic. An efficient and effective method for pandemic vaccination is the driving force of the research performed by our group. The proposed alternative vaccination technique consists of a self-administrable patch made of electrospun...
Rotator cuff tears are among the most common shoulder injuries that require surgery. High failure rates of biological graft-based repairs underscore the need for functional alternatives. In this study, effects of nanofiber organization on adhesion of cuff fibroblasts (hRCF) and human mesenchymal stem cells (hMSC) are evaluated. It is hypothesized that fiber alignment will regulate cell morphology...
Rotator cuff tears are among the most common shoulder injuries that require surgery. High failure rates of biological graft-based repairs underscore the need for functional alternatives. Specifically, functional grafts must incorporate the gradient of mineralization from tendon to bone in order to be biomimetic. In this study, effects of varying concentrations of mineral content in aligned nanofiber...
Dense, planar arrays consisting of molecular motors and their complementary filaments have been proposed for the bottom-up construction of a hybrid actuator. The following design metrics were established to quantify filament array quality defined as efficiency of force transduction along a single direction: number density, spatial distribution, orientation distribution. Theoretical models describing...
The current vaccination paradigm for the prevention of anthrax is insufficient to deal with a potential, widespread epidemic. To solve this issue, we propose a self-administrable vaccine patch capable of delivering the antigen of interest into the skin. This patch is comprised of solid-state nanofibers containing encapsulated protective antigen (PA), a binding protein secreted by Bacillus anthracis...
It is critical to fabricate ideal scaffolds for tissue engineered vascular graft. Nanofibers composted with collagen, elastin and polycaprolactone (PCL) were prepared by electrospinning. The obtained composite fibers had an average diameter around 300-500 nm. Mouse smooth muscles cells and endothelial cells cultured on these composite fibrous meshes showed enhanced cell attachment and accelerated...
Vertically aligned carbon nanofiber (VACNF) electrode arrays were tested for their potential application in recording neuro-chemical activity. Because the electrodes are carbon-based, these arrays have potential advantages over metal electrodes and could enable a variety of future applications as precise, informative, and biocompatible neural interfaces. Dopamine (DA) concentrations were recorded...
Wear-debris particles from ultrahigh molecular weight polyethylene (UHMWPE) and metals has been implicated in periprosthetic osteolysis and cellular response to them depend on their size and dose. Response to larger particles has been previously studied, but there are no specific studies examining biological response to simultaneous administration of both UHMWPE and Ti particles less than 0.2??m in...
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