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Current delivery systems for vaccines present major logistical problems when large populations need to be vaccinated within a short time period, such as in the case of a pandemic. An efficient and effective method for pandemic vaccination is the driving force of the research performed by our group. The proposed alternative vaccination technique consists of a self-administrable patch made of electrospun...
A skin patch composed of an electrospun nanofibrous membrane of a highly hygroscopic polymer, encasing a reversibly packaged antigen and adjuvant cocktail, promises a practical alternative to the current vaccine strategy. The proposed system would utilize the high density of antigen presenting (APC) cells found within the layers of human skin to elicit a vast adaptive immune response. The amount of...
Therapeutic delivery into the brain parenchyma is difficult due to the presence of the blood-brain barrier (BBB). One potential solution is to use cell-penetrating peptides (CPPs). CPPs are short peptides made up of primarily positively charged amino acids that have the ability to transduce cell membranes and deliver cargoes to cells. It is unclear, however, whether CPPs can penetrate cell barriers,...
Our design utilizes the venturi principle to accelerate an emulsification of powdered medication through a series of ribs, imparting shear and inertial forces to any particle agglomerates, separating them to a size suitable to be fully inspired and diffused into pulmonary circulation. A blister package, containing the medication, will be snapped into the inhaler, punctured, and emptied into the venturi...
The current vaccination paradigm for the prevention of anthrax is insufficient to deal with a potential, widespread epidemic. To solve this issue, we propose a self-administrable vaccine patch capable of delivering the antigen of interest into the skin. This patch is comprised of solid-state nanofibers containing encapsulated protective antigen (PA), a binding protein secreted by Bacillus anthracis...
Delivery of therapeutic compounds to the brain is limited, because due to their molecular size they cannot cross the blood-brain barrier (BBB). Focused ultrasound (FUS) after administration of microbubbles into the blood-stream has been shown to open the BBB locally, non-invasively and reversibly. In this study, we investigated the time required for BBB's permeability at the sonicated region to revert...
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