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We are testing degradation rates of calcium sulfate/polymer composites meant for use as bone graft substitutes. The goal is to demonstrate the potential of composite degradable and biocompatible materials that will resorb slower than pure calcium sulfate. We will determine which composites give us degradation profiles that are appropriate for different types of bone regeneration.
Rupture of abdominal aortic aneurysm (AAA) ranks as the 13th leading cause of death in the US. Fluid Structure Interaction (FSI) analysis was conducted with the aim of strengthening the current diagnostic measures of the disease, in particular, to (i) predict the location of wall rupture, (ii) estimate the state of pathology from the calculated ruptured potential index (RPI) and (iii) predict the...
The pluripotency of human embryonic stem cells (hESCs) provides the unique opportunity to derive tissue specific cells, an ability of particular interest in regenerative medicine. In the study of bone regeneration, there is interest in directing hESCs to mesenchymal stem cells (MSCs), which under the appropriate conditions gives rise to mineral-producing osteoblasts. To evaluate the efficiency of...
Rotator cuff tears often occur at the tendon-bone insertion site, a fibrocartilaginous interface that is not regenerated during current repairs. Our aim is to regenerate the insertion site through use of extracellular matrix based scaffolds. In this study, we evaluated the response of mineralized and non-mineralized nanofiber scaffolds to cell culture environment without the influence of cell growth...
The regeneration of the tendon to bone insertion site affects how well the ACL heals. The addition of a calcium phosphate coating to a tendon graft can help to promote osteointegration and healing of the insertion. Patellar tendons were harvested from neonatal bovines and coated in semi-crystalline calcium phosphate. The tendons were subjected to two 5?? concentrated simulated body fluid solutions...
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